摘要
目的研究慢性阻塞性肺疾病急性加重(acute exacerbation chronic obstructive pulmonary disease,AECOPD)合并支气管扩张患者病情评估中用力肺活量占预计值百分比(forced vital capacity as a percentage of expected value,FVC%perd)、第1秒用力呼气容积占预计值百分比(the percentage of forced expiratory volume in the first second to the expected value,FEV1%perd)、残气量/肺总量(residual gas volume/total lung volume,RV/TLC)与生化指标的相关性。方法以2021年1月—2023年6月南京市六合区人民医院收治的105例AECOPD合并支气管扩张患者为研究组,以同期在本院进行体检的105例健康志愿者为对照组,两组均检测FVC%perd、FEV1%perd、RV/TLC、C反应蛋白(C-reactive protein,CRP)及降钙素原(procalcitonin,PCT)水平并进行比较,同时分析不同指标的相关性。结果研究组RV/TLC高于对照组,FVC%perd、FEV1%perd均低于对照组,研究组PCT、CRP水平均高于对照组,差异有统计学意义(P<0.05)。RV/TLC与PCT、CRP水平为正相关,FVC%perd、FEV1%perd与PCT、CRP水平为负相关(P<0.05)。结论AECOPD合并支气管扩张患者FEV1%perd、FVC%perd水平与相关生化指标存在负相关关系,RV/TLC与相关生化指标存在正相关关系,可为临床上评估其病情提供参考。
Objective To study the correlation between the percentage of forced vital capacity as a percentage of expected value(FVC%perd),the percentage of forced expiratory volume in the first second to the expected value(FEV1%perd),residual gas volume/Total lung volume(RV/TLC)and biochemical parameters in patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)combined with bronchodilation.Methods 105 patients with AECOPD combined with bronchiectasis admitted to Nanjing Liuhe District People's Hospital from January 2021 to June 2023 were used as the study group,and 105 healthy volunteers who underwent physical examination in our hospital during the same period were used as the control group.FVC%perd,FEV1%perd,RV/TLC,C-reactive protein(CRP)and procalcitonin(PCT)were detected and compared between the two groups,and the correlation of the different indexes was also analyzed.Results RV/TLC in study group was higher than that in control group,FVC%perd and FEV1%perd were lower than those in control group,while PCT and CRP levels in study group were higher than those in control group,the differences were statistically significant(P<0.05).RV/TLC was positively correlated with PCT and CRP levels,FVC%perd and FEV1%perd were negatively correlated with PCT and CRP levels(P<0.05).Conclusion There is a negative correlation between the levels of FEV1%perd,FVC%perd,RV/TLC and the related biochemical indexes and a positive correlated between the level of RV/TLC and the related biochemical indexes in patients with AECOPD combined with bronchiectasis,which may provide a reference for the clinical assessment of their conditions.
作者
刘文增
LIU Wenzeng(Department of Respiratory Medicine,Nanjing Liuhe District People's Hospital,Nanjing,Jiangsu Province,211500 China)
出处
《世界复合医学》
2023年第10期102-105,共4页
World Journal of Complex Medicine
关键词
慢性阻塞性肺疾病
支气管扩张
肺功能
Chronic obstructive pulmonary disease
Bronchiectasis
Lung function
