摘要
目的探讨改良电休克治疗重度抑郁症患者的临床效果及安全性。方法选取2018年9月至2019年9月在我院治疗的重度抑郁症患者86例为研究对象,采用随机数字法分为对照组和观察组,每组43例。对照组患者进行传统电休克治疗,观察组患者进行改良电休克治疗,每例患者治疗6~12次。比较两组患者治疗前、治疗结束后的临床总体印象-严重度量表(CGI-S)评分和血浆犬尿氨酸水平;比较两组患者的临床疗效以及不良反应发生情况。结果治疗前,两组患者的CGI-S评分、犬尿氨酸水平比较,差异无统计学意义(P>0.05);疗程结束后,观察组患者的CGI-S评分以及犬尿氨酸水平均显著低于对照组,差异有统计学意义(P<0.05)。观察组患者的治疗总有效率(93.02%)显著高于对照组(76.74%),差异有统计学意义(P<0.05)。治疗开始至治疗结束后2个月,观察组患者的不良反应发生率(27.91%)显著低于对照组(48.84%),差异有统计学意义(P<0.05)。结论改良电休克治疗重度抑郁症患者的疗效明显优于传统电休克治疗,可显著降低患者的犬尿氨酸水平,减少不良反应的发生。
Objective To explore the clinical effect and safety of modified electroconvulsive therapy in the treatment of patients with major depressive disorder.Methods A total of 86 patients with major depressive disorder who were treated in our hospital from September 2018 to September 2019 were selected as the research objects,and they were divided into control group and observation group according to the random number method,with 43 cases in each group.The control group was given traditional electroconvulsive therapy,whereas the observation group was given modified electroconvulsive therapy.Each patient was treated 6 to 12 times.The Clinical Global Impression Severity Scale(CGI-S)scores and plasma kynurenine levels of the two groups before and after treatment were compared.The clinical efficacy and adverse reactions of the two groups were compared.Results Before treatment,there were no statistically significant differences in CGI-S scores and kynurenine levels between the two groups(P>0.05).After the treatment course,the observation group yielded lower CGI-S score and kynurenine level in comparison with the control group,with statistically significant differences(P<0.05).The total effective rate in the observation group(93.02%)was significantly higher than that in the control group(76.74%),with a statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group(27.91%)was significantly lower than that in the control group(48.84%)from the beginning to 2 months after the end of treatment,with a statistically significant difference(P<0.05).Conclusion The efficacy of modified electroconvulsive therapy is significantly superior to traditional electroconvulsive therapy in the treatment of patients with major depression disorder.It can significantly decrease the levels of kynurenine in patients,and reduce the occurrence of adverse reactions.
作者
薛峰
李云珍
李引涛
XUE Feng;LI Yunzhen;LI Yintao(Department of Psychiatry,Sanmenxia Rehabilitation Hospital,Sanmenxia 472000,Henan Province,China)
出处
《内科》
2021年第5期596-598,607,共4页
Internal Medicine
基金
2019年河南省医学科技攻关计划联合共建项目(LHGJ20190462)。
关键词
重度抑郁症
电休克
改良电休克疗法
效果
Major depressive disorder
Electroconvulsive therapy
Modified electroconvulsive therapy
Effect
