摘要
目的探讨口腔扁平苔藓(OLP)患者血清血管生成素-2(Ang-2)水平与叉头翼状螺旋转录因子(Foxp3)阳性调节性T淋巴细胞(Treg)及疾病活动度相关性分析。方法选取113例不同分型OLP患者为研究对象(试验组),其中网纹型45例,充血型36例,糜烂型32例。另选取健康志愿者76例设为对照组。血清Ang-2和Foxp3+Treg水平分别采用酶联免疫吸附法和流式细胞仪进行检测。统计OLP患者临床体征评分、OLP网纹-萎缩-糜烂(RAE)病损评分和疾病活动评分。采用Pearson相关性分析明确Ang-2水平与Foxp3+Treg及各评分的相关性。结果与对照组相比,不同分型OLP患者血清Ang-2、Foxp3+Treg水平均升高(P<0.05);与网纹型相比,糜烂型和充血型患者血清Ang-2、Foxp3+Treg水平升高(P<0.05);与充血型相比,糜烂型患者血清Ang-2、Foxp3+Treg水平升高(P<0.05)。糜烂型和充血型患者临床体征评分、RAE病损评分、疾病活动评分均高于网纹型(P<0.05);与充血型患者相比,糜烂型患者上述指标水平升高(P<0.05)。OLP患者血清Ang-2水平与Foxp3+Treg、临床体征评分、RAE病损评分、疾病活动评分均呈正相关(r值分别为0.531、0.548、0.554、0.528,P<0.001)。结论血清Ang-2水平在OLP患者体内异常升高,且其升高程度与患者Foxp3+Treg水平、临床体征、病损程度及疾病活动程度呈正相关。
Objective This study aims to explore the relationship between serum angiopoietin-2(Ang-2)levels and forkhead/winged helix transcription factor p3(Foxp3)-positive regulatory T cells(Treg)and disease activity in patients with oral lichen planus(OLP).Methods A total of 113 patients with different types of OLP were selected(observation group),including 45 cases of reticular type,36 cases of hyperemia type,and 32 cases of erosion type.Another 76 healthy volunteers(control group)were included.Serum Ang-2 and Foxp3+Treg levels were detected by enzyme-linked immunosorbent assay and flow cytometry,respectively.Clinical sign scores,reticular-atrophic-erosive(RAE)lesion scores and disease activity scores of patients with OLP were analyzed.Pearson correlation analysis was used to clarify the correlation between each score and levels of Ang-2 and Foxp3+Treg.Results The levels of Ang-2 and Foxp3+Treg in the serum of patients with OLP of different types were higher than those in the control group(P<0.05).The serum levels of Ang-2 and Foxp3+Treg were higher in patients with erosive and hyperemia types than in patients with the reticuloid type(P<0.05).Compared with the hyperemia type,the serum levels of Ang-2 and Foxp3+Treg in patients with erosive type were higher(P<0.05).The clinical sign scores,RAE lesion scores,and disease activity scores of erosive and hyperemic patients were higher than those of patients with the reticulated type(P<0.05).Patients with erosion type had higher levels of the above indices than patients with the hyperemia type(P<0.05).The serum levels of Ang-2 in patients with OLP was positively correlated with Foxp3+Treg,clinical sign scores,RAE lesion scores,and disease activity scores(r=0.531,0.548,0.554,0.528,P<0.001).Conclusion Serum Ang-2 levels were abnormally elevated in patients with OLP,and the level of elevation was positively correlated with Foxp3+Treg levels,clinical signs,lesions,and disease activity.
作者
王素杰
谭芹
韦渊
王洁
范杰
岳二丽
Wang Sujie;Tan Qin;Wei Yuan;Wang Jie;Fan Jie;Yue Erli(Dept.of Stomatology,The First People’s Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2023年第6期674-678,共5页
International Journal of Stomatology
