摘要
目的 探讨替罗非班对血管内介入治疗急性缺血性脑卒中(AIS)患者预后的影响。方法选取2020年3月至2022年3月重庆市开州区人民医院和恩施土家族苗族自治州中心医院共同收治的102例AIS患者,随机分为观察组(51例)和对照组(51例)。对照组接受血管内介入术治疗,观察组在对照组基础上给予替罗非班治疗。比较两组治疗有效率、药物安全性、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、改良RANKIN量表(mRS)评分、脑源性神经营养因子(BDNF)、神经生长因子(NGF)、S100 β及血小板功能指标。结果 观察组和对照组治疗总有效率分别为74.51%、60.78%,差异无统计学意义(P>0.05)。治疗后,观察组NIHSS评分、mRS评分、血清S100 β水平及血小板聚集率、血小板黏附率、最大聚集时间均低于对照组,而血清BDNF、NGF水平明显高于对照组(P<0.05)。两组患者任何出血、症状性颅内出血(sICH)、复发率及病死率差异无统计学意义(P>0.05)。结论 替罗非班辅助血管内介入术治疗AIS可有效改善患者血小板功能,促进神经功能恢复,且安全性良好。
Objective To investigate the effect of tirofiban on the prognosis of patients with acute ischemic stroke(AIS)after endovascular intervention therapy.Methods From March 2020 to March 2022,102 AIS patients who were jointly treated in Chongqing Kaizhou District People's Hospital and Enshi Tujia and Miao Autonomous Prefecture Central Hospital were selected and randomly divided into observation group(51 cases)and control group(51 cases).The control group received endovascular intervention treatment,and the observation group received tirofiban treatment on the basis of the control group.The efficacy rate,drug safety,national Institutes of Health Stroke Scale(NIHSS)score,modified RANKIN Scale(mRS)score,brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),S100βand platelet function indexes before and after treatment were compared between two groups.Results The total effective rate of the observation group and the control group were 74.51%and 60.78%and the difference was not statistically significant(P>0.05).After treatment,NIHSS score,mRS score,serum S100βlevel,platelet aggregation rate,platelet adhesion rate and maximum aggregation time in observation group were lower than those in control group,while serum BDNF and NCF levels were significantly higher than those in control group(P<0.05).There were no significant differences in bleeding,symptomatic intracranial hemorrhage(sICH),recurrence rate and mortality between 2 groups(P>0.05).Conclusion Tirofiban assisted endovascular intervention in the treatment of AIS can effectively improve the platelet function and promote the recovery of nerve function with good safety.
作者
王彬
杜杰
李杰
Wang Bin;DuJie;Li Jie(Department of Neurology,People's Hospital of Kaizhou District,Chongqing,Chongqing 405400,China)
出处
《脑与神经疾病杂志》
CAS
2023年第9期534-538,共5页
Journal of Brain and Nervous Diseases
基金
湖北省卫生厅科研指导性项目(JX6C-61)。
