摘要
目的探讨在未接受溶栓或取栓治疗的急性缺血性脑卒中(AIS)患者发病24 h内,应用替罗非班联合丁苯酞治疗的临床效果及潜在优势。方法纳入60例发病24 h内未行溶取栓治疗的急性缺血性脑卒中患者,按随机数字表法分为两组:对照组(30例)单独使用替罗非班,观察组(30例)采用替罗非班联合丁苯酞治疗方案。对比两组疗效、神经功能、日常生活能力、炎症指标。结果观察组治疗总有效率96.67%高于对照组的73.33%(P<0.05)。治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分(6.00±0.52)分、超敏C反应蛋白(4.19±1.05)mg/L、白细胞介素-6(18.77±3.23)ng/L低于对照组的(7.89±1.33)分、(5.66±1.33)mg/L、(28.96±4.89)ng/L,改良Barthel指数评分(69.89±8.78)分高于对照组的(57.93±7.52)分(P<0.05)。结论发病24 h内未行溶取栓治疗的急性缺血性脑卒中患者给予替罗非班与丁苯酞联合治疗有助于提高疗效,改善神经功能,降低炎症指标,应用价值高。
Objective explore the clinical effect and potential advantages of tirofiban combined with butylphthalide on patients with acute ischemic stroke(AIS)without thrombolytic therapy within 24 h of onset.Methods 60 patients with acute ischemic stroke who did not receive thrombolytic therapy within 24 h of onset were included.They were divided into two groups by the random number table method,with the control group(30 cases)receiving tirofiban treatment,and the observation group(30 cases)receiving the combined treatment of tirofiban and butylphthalide.The therapeutic effects,neurological function,daily living ability and inflammatory markers of the two groups were compared.Results The total effective rate of treatment 96.67%in the observation group was significantly higher than 73.33%in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in the observation group was(6.00±0.52)points,the hypersensitive C-reactive protein was(4.19±1.05)mg/L,and the interleukin-6 was(18.77±3.23)ng/L,which were lower than those in the control group[(7.89±1.33)points,(5.66±1.33)mg/L,and(28.96±4.89)ng/L];the modified Barthel index score(69.89±8.78)points in the observation group was higher than(57.93±7.52)points in the control group(P<0.05).Conclusion For patients with acute ischemic stroke who have not undergone thrombolytic therapy within 24 h of onset,combined treatment of tirofiban and butylphthalide is helpful to enhance the therapeutic effect,and can improve neurological function and reduce inflammatory markers.It has high application value.
作者
申慧
吴冬
SHEN Hui;WU Dong(Chifeng Municipal Hospital,Chifeng 024000,China)
出处
《中国实用医药》
2025年第20期95-98,共4页
China Practical Medicine
