摘要
综述中药调控核转录因子-κB(NF-κB)信号通路防治子宫内膜异位症(EMT)作用机制的研究进展。近年来运用中药单体及复方调控NF-κB信号通路治疗EMT成为研究热点,中药治疗EMT可通过抑制NF-κB信号通路调控包括基质金属蛋白酶(MMPs)家族、白介素(IL)家族、环氧合酶-2(COX-2)、血管内皮生长因子(VEGF)、前列腺素E2(PGE2)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)等靶基因的表达,起到抗炎及抑制细胞增殖、黏附、侵袭作用,进而阻滞细胞周期,促进细胞凋亡,抑制血管生成。
The research progress on the mechanism of traditional Chinese medicine(TCM)in regulating nuclear transcription factor-κB(NF-κB)signaling pathway to prevent endometriosis(EMT)is reviewed.In recent years,the use of TCM monomer and compound to regulate the NF-κB signaling pathway in the treatment of EMT has become a research focus.TCM plays an anti-inflammatory role by inhibiting the NF-κB signaling pathway that regulates the expression of target genes,including the matrix metalloproteinases(MMPs)family,interleukin(IL)family,cyclooxygenase-2(COX-2),vascular endothelial growth factor(VEGF),prostaglandin E2(PGE2),intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1),etc.These together act as anti-inflammatory and inhibit cell proliferation,adhesion,and invasion,then block the cell cycle,promote apoptosis,inhibit angiogenesis.
作者
刘洋
王宇
丛晶
韩布威
马丽娜
葛航
罗蓉
张蓓
吴效科
LIU Yang;WANG Yu;CONG Jing;HAN Buwei;MA Li'na;GE Hang;LUO Rong;ZHANG Bei;WU Xiaoke(Graduate School of Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150040,China;The First Department of Gynecology,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;Obstetrics and Gynecology Department of Xuzhou Central Hospital,Xuzhou,Jiangsu 221000,China)
出处
《上海中医药杂志》
CSCD
2023年第8期89-95,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家重点研发计划中医药现代化研究项目(2019YFC1709500)
黑龙江省中医药管理局2022年度中医药科研项目(ZHY2022-124)
黑龙江省中医药学会2022-2024年度青年人才托举工程项目(2022-QNRC1-02)
2019年度黑龙江中医药大学科研-博士创新基金项目(2019BS09)
徐州市卫健委引进临床医学专家团队-刘以训院士中西医结合妇产生殖技术创新团队项目(2019TD005)。
关键词
子宫内膜异位症
NF-ΚB信号通路
中药
作用机制
研究进展
endometriosis
NF-κB signaling pathway
traditional Chinese medicine
mechanism of action
research progress
