摘要
目的探究老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者肌肉量减少与尿白蛋白定量之间的关系。方法于2018年1月—2021年12月选取龙岩市第二医院180例肌肉量正常T2DM患者(肌肉量正常组)、180例肌肉量减少T2DM患者(肌肉量减少组),检测两组患者的尿白蛋白定量,比较两组蛋白尿发生率;并比较两组一般资料、各项实验室指标,在此基础上展开多因素Logistic回归分析,判断24 h尿白蛋白定量是否为T2DM肌肉量减少的独立影响因素;再根据360例患者24 h尿白蛋白定量水平分为A组(<0.15 g/24 h)、B组(0.15~1.00 g/24 h)、C组(1.00~3.50 g/24 h)、D组(>3.50 g/24 h)共4组,比较4组患者肌肉量减少发生率,分析24 h尿白蛋白定量与肌肉量减少的相关性。结果肌肉量减少组蛋白尿检出率28.33%,高于肌肉量正常组的7.78%,差异有统计学意义(P<0.05)。肌肉量减少组患者年龄、T2DM病程、UACR、24 h尿白蛋白定量高于肌肉量正常组,eGFR、RSMI低于肌肉量正常组,差异有统计学意义(P<0.05);两组患者其他指标比较,差异无统计学意义(P>0.05)。经Logistic回归分析证实,24 h尿白蛋白定量是T2DM肌肉量减少的独立影响因素(OR=2.01,95%CI:1.15~3.47,P<0.05)。24 h尿白蛋白定量越高,肌肉量减少发生率越高,二者呈正相关(r=0.453,P<0.05)。结论T2DM患者肌肉量与蛋白尿呈负相关,蛋白尿含量为肌肉量减少的独立危险因素。
Objective To explore the relationship between muscle mass loss and urinary albumin quantification in elderly patients with type 2 diabetes mellitus(T2DM).Methods From January 2018 to December 2021,180 patients with normal muscle mass T2DM(normal muscle mass group)and 180 patients with reduced muscle mass T2DM(muscle mass reduction group)admitted to Longyan Second Hospital were selected to measure the urinary albumin content of the two groups of patients and compare the incidence of proteinuria between the two groups;compared the general data and various laboratory indicators between the two groups,and conducted multivariate logistic regression analysis on this basis to determine whether 24-hour urinary albumin quantification was an independent influencing factor for T2DM muscle mass reduction;360 patients were divided into four groups according to their 24-hour urinary albumin quantification levels:Group A(<0.15 g/24 h),Group B(0.15~1.00 g/24 h),Group C(1.00~3.50 g/24 h),and Group D(>3.50 g/24 h).The incidence of muscle mass loss in the four groups was compared,and the correlation between 24-hour urinary albumin and muscle mass loss was analyzed.Results The detection rate of proteinuria in the muscle mass reduction group was 28.33%,higher than 7.78%in the normal muscle mass group,and the difference was statistically significant(P<0.05).The age,course of T2DM,UACR,and 24 h urinary albumin quantification of patients in the muscle mass reduction group were higher than those of patients in the normal muscle mass group,while the eGFR and RSMI were lower than those of patients in the normal muscle mass group,and the difference was statistically significant(P<0.05);there was no statistically significant difference in other indicators between the two groups(P>0.05).Logistic regression analysis confirmed that 24-hour urinary albumin quantification was an independent influencing factor for T2DM muscle mass reduction(OR=2.01,95%CI:1.15-3.47,P<0.05).The higher the 24-hour urinary albumin content,the higher the incidence of muscle mass reduction,and there was a positive correlation between the two(r=0.453,P<0.05).Conclusion There is a negative correlation between muscle mass and proteinuria in T2DM patients,and proteinuria content is an independent risk factor for decreased muscle mass.
作者
蓝梅金
卢娟
黄彬三
邱莉
LAN Meijin;LU Juan;HUANG Binsan;QIU Li(Department of Nephrology,Longyan Second Hospital,Longyan,Fujian Province,364000 China)
出处
《糖尿病新世界》
2023年第5期13-17,共5页
Diabetes New World Magazine
基金
龙岩市科技计划项目(2020LYF17048)。
关键词
2型糖尿病
老年
肌肉量减少
蛋白尿
Type 2 diabetes mellitus
Elderly
Decreased muscle mass
Urine protein
