摘要
目的探讨初诊2型糖尿病尿微量白蛋白与尿肌酐比值的危险因素。方法选取2019年5月—2020年12月于该院住院治疗的114例初诊2型糖尿病患者,测定尿微量白蛋白与尿肌酐比值(ACR),分为ACR阴性组(ACR<30 mg/g)和ACR阳性组(ACR≥30 mg/g)。对两组患者临床资料进行分析比较,并进一步将ACR与相关指标进行多因素Logistic回归分析。结果该研究共纳入114例患者,ACR阴性患者74例,ACR阳性患者40例,ACR的阳性率为35.1%;两组患者相关临床资料比较,ACR阳性组中收缩压、舒张压、HbA1c、TC、LDL-C、女性患者比例(20/74)显著高于ACR阴性组,差异有统计学意义(t=3.963、3.024、2.167、3.914、3.773,χ^(2)=6.016, P<0.05);年龄、FPG、2 hPG、BMI、TG、HDL-C、UA在两组患者中差异无统计学意义(P>0.05);进一步多因素Logistic回归分析发现收缩压、TC、HbA1c为ACR阳性的危险因素。结论收缩压、TC、HbA1c是初诊2型糖尿病ACR阳性的独立危险因素。
Objective To explore the risk factors of the ratio of urine microalbumin to urine creatinine in newly diagnosed type 2 diabetes. Methods Selected 114 newly diagnosed type 2 diabetes patients who were hospitalized in the hospital from May 2019 to December 2020. The ratio of urinary microalbumin to creatinine(ACR) was determined and divided into ACRnegative group(ACR<30 mg/g) and ACR-positive group(ACR≥30 mg/g). The clinical data of the two groups of patients were analyzed and compared, and the ACR and related indicators were further analyzed by multivariate Logistic regression.Results A total of 114 patients were enrolled in the study, 74 were ACR-negative patients, and 40 were ACR-positive patients. The positive rate of ACR was 35.1%. Compared the relevant clinical data of the two groups of patients, the systolic blood pressure, diastolic blood pressure, HbA1 c, TC, LDL-C, and the proplrtion of female patients(20/74) in the ACR positive group were significantly higher than those in the ACR negative group, and the difference was statistically significant(t=3.963, 3.024,2.167,3.914,3.773,χ^(2)=6.016, P<0.05). There was no statistically significant difference in age, FPG, 2 hPG,BMI, TG, HDL-C, UA between the two groups of patients(P>0.05). Further multivariate logistic regression analysis found that systolic blood pressure, TC, and HbA1c were risk factors for positive ACR. Conclusion Systolic blood pressure, TC and HbA1c are the independent risk factors of newly diagnosed type 2 diabetes with positive ACR.
作者
余翠
YU Cui(Department of Endocrinology and Genetic Metabolism,the Second Affiliated hospital of Wannan Medical College,Wuhu,Anhui Province,241001 China)
出处
《糖尿病新世界》
2021年第21期24-26,31,共4页
Diabetes New World Magazine
基金
皖南医学院中青年科研基金(WK2018F31)。
关键词
糖尿病
尿微量白蛋白
危险因素
Diabetes mellitus
Microalbuminuria
Risk factor
