摘要
目的 探讨老年T2DM患者基线血尿酸(SUA)及UACR与认知功能障碍的相关性。方法 选取中国台湾李氏联合诊所定期随访的老年T2DM患者1071例。每年定期随访,平均随访5年。根据随访过程中有无明显认知功能障碍分为明显认知功能障碍组(CI,n=173)和无明显认知功能障碍组(NCI,n=898)。根据基线UACR将CI组分为正常蛋白尿亚组(NUA,UACR<30 mg/g)、微量蛋白尿亚组(MUA,30≤UACR≤300 mg/g)和大量蛋白尿亚组(LUA,UACR>300 mg/g),比较认知功能障碍患病比例。分析CI、NCI两组临床特征、SUA、UACR与认知功能障碍的相关性。结果与NCI组比较,CI组年龄、饮酒史比例、Ins治疗比例、口服降糖药加Ins治疗比例、降压药使用、HbA1c、血肌酐(Scr)及UACR升高(P<0.05)。Pearson相关分析显示,认知功能障碍与年龄、Ins治疗比例、口服降糖药加Ins治疗比例、降压药使用、HbA1c、Scr及UACR呈正相关(P<0.05),与饮酒史比例呈负相关(P<0.05)。Logistic回归分析显示,HbA1c和LUA是认知功能障碍的危险因素。结论老年T2DM患者认知功能障碍与基线UACR密切相关,UACR>300 mg/g是认知功能障碍的危险因素。
Objective To assess the impact of baseline serum uric acid(SUA)and urinary albumin/creatinine ratio(UACR)on cognitive impairment in elderly patients with type 2 diabetes mellitus(T2DM).Methods This prospective cohort study included 1071 type 2 diabetes mellitus(T2DM)patients who were regularly followed up in Lee’s clinic.Patients were regularly followed up annually with an average of 5 years.The group was divided into cognitive impairment group(CI,n=173)and no significant cognitive impairment group(NCI,n=898)according to the presence or absence of significant cognitive impairment during follow-up.All participants were also divided into three groups according to baseline UACR values:NUA(UACR<30 mg/g),MUA(30≤UACR≤300 mg/g),and LUA(UACR>300 mg/g).The clinical characteristics of CI and NCI and the correlation between SUA,UACR,and cognitive impairment were analyzed.Results Compared with NCI group,age,proportion of drinking,insulin use rate,oral hypoglycemic drugs and insulin use rate,anti-hypertensive drugs use rate,HbA1c,Scr,and UACR were all higher in CI group(P<0.05).Pearson correlation analysis showed that cognitive impairment was positively correlated with age,insulin use rate,oral hypoglycemic drugs and insulin use rate,anti-hypertensive drugs use rate,HbA1c,Scr,and UACR(P<0.05),while negatively correlated with proportion of drinking(P<0.05).Logistic regression analysis showed that LUA and HbA1c were risk factors for cognitive dysfunction.Conclusion There is a close relationship between cognitive impairment and UACR in elderly T2DM patients.UACR>300 mg/g is an independent risk factor for cognitive impairment.
作者
刘婧茹
袁晓丹
刘欢欢
李洮俊
史素玲
楼青青
LIU Jingru;YUAN Xiaodan;LIU Huanhuan(Henan University of Science and Technology School of Nursing,Luoyang 471000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2023年第3期187-190,共4页
Chinese Journal of Diabetes
基金
国家重点研发计划项目(2021YFE0204800)。
关键词
糖尿病
2型
认知功能障碍
UACR
血尿酸
Diabetes mellitus,type 2
Cognitive impairment
Urinary albumin/creatinine ratio
Serum uric acid
