摘要
目的探讨Survivin、胰岛素样生长因子ⅡmRNA结合蛋白3(insulin-like growth factorⅡmRNA-binding protein 3,IMP3)及Claudin1在浆膜腔积液细胞蜡块中的表达及临床意义。方法收集我院病理科2017年2月~2021年11月行免疫组化检查且临床资料齐全的浆膜腔积液细胞块95例,其中恶性84例,良性11例(对照组)。应用免疫组化方法检测浆膜腔积液细胞蜡块中Survivin、IMP3及Claudin1蛋白的表达情况,并对比分析其在良恶性浆膜腔积液以及不同恶性肿瘤中的差异。结果恶性胸膜腔积液病例中胸腔积液53例,腹腔积液31例。肺腺癌41例,消化系统腺癌25例,卵巢恶性肿瘤9例,其他恶性肿瘤9例。与对照组相比,肺腺癌组及消化系统腺癌组IMP3的表达差异具有统计学意义(P<0.05),消化系统腺癌组Claudin1的表达差异具有统计学意义(P<0.05),其他组别Survivin、IMP3及Claudin1的表达与对照组相比差异均无统计学意义(P>0.05)。结论IMP3及Claudin1在恶性浆膜腔积液判断是否为消化系统腺癌来源时具有鉴别意义,IMP3在肺腺癌来源具有鉴别意义。
Objective To investigate the expression and clinical significance of Survivin,IMP3 and Claudin1 in cell paraffin section of serosal cavity effusion.Methods A total of 95 cell paraffin section of serous cavity effusion in our hospital from Feb 2017 to Nov 2021 that completed clinical data were enrolled in the study,including 81 cases malignant and 11 benignant.The expression of Survivin,IMP3 and Claudin1 were examined by immunohistochemistry and compared the difference.Results Malignant cases included 53 cases of hydrothorax,31 cases of ascites.41 cases of lung adenocarcinoma,25 case of digestive system adenocarcinoma,9 case of ovarian neoplasm and 9 cases of other malignancies.Compared with the control group,there were significant differences in the IMP3 expression of lung adenocarcinoma(P<0.05)and digestive system adenocarcinoma and Claudin1 expression of digestive system adenocarcinoma(P<0.05),and the expressions in other groups were no statistically significant(P>0.05).Conclusion IMP3 and Claudin1 have differential significance in determining whether malignant serous cavity effusion is the source of digestive system adenocarcinoma,while IMP3 has differential significance in identifying the source of lung adenocarcinoma.
作者
韩永良
汪亮亮
王洁
赵锐
Han Yongliang;Wang Liangliang;Wang Jie(Department of Pathology,Jiujiang No.1 People's Hospital,Jiujiang 332000)
出处
《中国现代医药杂志》
2023年第4期21-25,共5页
Modern Medicine Journal of China
基金
江西省卫生健康委科技计划项目(编号:202140256)。
