摘要
新型冠状病毒感染相关的神经系统病变临床表现多样,包括头痛、精神障碍、急性脑(膜)炎、急性播散性脑脊髓膜炎、吉兰-巴雷综合征、急性脑病,甚至急性(出血性)坏死性脑病等,可归因于多种潜在的病理生理机制,以细胞因子风暴、血管内皮损伤(包括血脑屏障)和缺氧缺血性损伤等为主,其严重程度决定了感染者的预后。治疗以一般支持治疗及免疫调节为主。临床医生需对患儿的脑功能障碍程度和预后进行监测、评估,并及时干预。
The clinical manifestations of neuropathies associated with novel coronavirus infection are diverse,including headache,mental disorders,acute encephalitis(meningitis),acute disseminated cerebrospinal meningitis,Guillain-Barre syndrome,acute encephalopathy and even acute(hemorrhagic)necrotic encephalopathy,which can be attributed to a variety of potential pathophysiological mechanisms.The severity of cytokine storm,vascular endothelial cell injury(including blood-brain barrier)and hypoxic ischemic injury determines the prognosis of infected patients.The treatment mainly includes general supportive therapy and immune regulation.Clinicians need to monitor and evaluate the degree of brain dysfunction and prognosis,and ensure timely treatment.
作者
王荃
Wang Quan(Department of Emergency,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)
出处
《中国小儿急救医学》
CAS
2023年第3期161-165,共5页
Chinese Pediatric Emergency Medicine
