摘要
急性坏死性脑病(ANE)是一种以意识障碍为主要表现、影像学显示对称性双侧丘脑坏死为特征的急性脑病,死亡率高,存活者多留有较严重的神经系统后遗症。ANE常继发于病毒感染,特别是流感病毒感染。在最近3年的新型冠状病毒(SARS-CoV-2)感染全球流行中,ANE已经成为引起儿童重症和死亡的主要并发症之一,引起了广泛关注。现就流感病毒和SARS-CoV-2引起ANE的流行病学、发病机制、诊断、治疗及预后进展进行阐述,以期提高临床医师对该病的认识。
Acute necrotizing encephalopathy(ANE)is a subtype of acute encephalopathy presented with disturbance of consciousness and symmetric bilateral thalamic necrosis in neuroradiology.Patients with ANE had a high mortality or severe neurological sequela.ANE usually secondary to virus infectious disease,in which influenza is a common etiology.During the 3 years of the worldwide pandemic of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,ANE has become a severe complication and cause of death in children,which has aroused much concern.Here is a review of the research progress of epidemiology,pathogenesis,diagnosis,treatments and prognosis of ANE,in order to improve the knowledge of clinicians on this disease.
作者
陈杰华
郑跃杰
何颜霞
申昆玲
Chen Jiehua;Zheng Yuejie;He Yanxia;Shen Kunling(Department of Respiratory,Shenzhen Children′s Hospital,Shenzhen 518038,China;Department of Pediatric Intensive Care Unit,Shenzhen Children′s Hospital,Shenzhen 518038,China;Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,China National Clinical Research Center of Respiratory Diseases,National Center for Children′s Health,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2023年第1期10-16,共7页
Chinese Journal of Applied Clinical Pediatrics
基金
深圳市医学重点学科建设经费(SZXK032)
关键词
流感病毒
新型冠状病毒
急性坏死性脑病
儿童
Influenza virus
Severe acute respiratory syndrome coronavirus 2
Acute necrotizing encephalopathy
Child
