摘要
目的 探讨不同冷光源光疗法对新生儿黄疸疗效、疾病转归进程的影响及不良反应发生情况。方法 选取新生儿黄疸患儿480例,按照随机数字表法分组,各240例。对照组给予持续性冷光源光疗,观察组给予多次间歇冷光源光疗。治疗1周后,比较2组治疗效果、疾病转归进程、治疗前后黄疸指数、血清总胆红素(total bilirubin,TBIL)、总胆汁酸(total bile acid,TBA)水平、炎症因子[C反应蛋白(C reactive protein,CRP)、白细胞介素2(interleukin 2,IL-2)、白细胞介素6(interleukin 6,IL-6)]、听觉传导通路变化情况及不良反应。结果 观察组总有效率97.08%(233/240)高于对照组90.00%(216/240)(P<0.05);观察组胎便转黄时间、TBIL降至正常时间、黄疸消退时间、住院时间短于对照组(P<0.05);治疗1周后观察组黄疸指数、血清TBIL、TBA水平低于对照组(P<0.05);治疗1周后观察组血清CRP、IL-2、IL-6水平低于对照组(P<0.05);治疗1周后观察组波间反应阈、潜伏期Ⅰ值低于对照组(P<0.05);观察组不良反应发生率23.75%(57/240)低于对照组41.67%(100/240)(P<0.05)。结论 多次间歇冷光源光疗应用于新生儿黄疸疗效优于持续性冷光源光疗,可有效加速疾病转归进程,改善高TBIL、黄疸等症状体征,减轻炎症反应,降低患儿听觉波间反应阈,还可减少不良反应发生。
Objective To investigate the effect of different cold-light phototherapy on the efficacy of neonatal jaundice and disease progression,and the occurrence of adverse reactions.Methods A total of 480 children with neonatal jaundice were selected and grouped according to the random number table method,with 240 cases in each group.The control group was given continuous cold-light phototherapy,and the observation group was given multiple intermittent cold-light phototherapy.At 1 week after treatment,the therapeutic effect,disease progression,jaundice index,serum total bilirubin(TBIL),total bile acid(TBA)levels,inflammatory factors[C-reactive protein(CRP),interleukin(IL-2),interleukin-6(IL-6)]before and after treatment,auditory conduction pathway changes and adverse reactions were compared between two groups.Results The total effective rate in the observation group was 97.08%(233/240),which was higher than 90.00%(216/240)in the control group(P<0.05).The time for meconium to turn yellow,the time for TBIL to return to normal,the time for jaundice to subside,and the length of hospitalization were shorter in the observation group than in the control group(P<0.05).At 1 week after treatment,the jaundice index,serum TBIL and TBA levels in the observation group were lower than those in the control group(P<0.05);The serum CRP,IL-2 and IL-6 levels in the observation group were lower than those in the control group at 1 week after treatment(P<0.05).At 1 week after treatment,the interwave reaction threshold and latencyⅠvalue of the observation group were lower than those of the control group(P<0.05);the incidence of adverse reactions in the observation group was 23.75%(57/240)lower than 41.67%(100/240)in the control group(P<0.05).Conclusion Multiple intermittent cold-light phototherapy in neonatal jaundice is more effective than continuous cold-light phototherapy,which can effectively speed up the progression of the disease,improve symptoms and signs of high TBIL and jaundice,reduce inflammatory response,lower the threshold of auditory interwave response in children,and reduce the occurrence of adverse reactions.
作者
王占晖
丁明欣
柴清华
刘雪
WANG Zhan-hui;DING Ming-xin;CHAI Qing-hua;LIU Xue(Department of Pediatrics,Jiaozhou Central Hospital,Shandong Province,Qingdao 266300,China)
出处
《河北医科大学学报》
CAS
2023年第4期454-458,共5页
Journal of Hebei Medical University
基金
青岛市医药卫生科研计划项目。
关键词
黄疸
新生儿
冷光源光疗法
总胆红素
jaundice,neonatal
cold-lightphototherapy
total bilirubin
