摘要
目的探讨葛酮通络胶囊联合丁苯酞治疗大动脉粥样硬化型(atherosclerosis of aorta,LAA)急性脑梗死的疗效及对心型脂肪酸结合蛋白(heart-shaped fatty acid binding protein,H-FABP)的影响。方法选择168例发病48 h内诊断为LAA型急性脑梗死的患者作为研究对象,采用随机数字法将患者分为观察组与对照组,对照组给予常规治疗方案及丁苯酞氯化钠注射液治疗,观察组在对照组基础上加用葛酮通络胶囊治疗。于治疗前,治疗后7 d、14 d采用美国国立卫生院卒中量表(American national institutes of health stroke scale,NIHSS)进行神经功能缺损评价;于治疗前,治疗后3 d、7 d及14 d清晨空腹抽血采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测H-FABP水平。随访3月采用改良Rankin量表(modified rankin scale,mRS)对日常生活能力进行评价。结果观察组总有效率为92.86%(78/84),高于对照组总有效率82.14%(69/84)(P<0.05)。随着治疗时间延长,两组患者NIHSS评分及H-FABP水平整体呈下降趋势,治疗后14 d观察组NIHSS评分明显低于对照组(P<0.05)。治疗后3 d、7 d及14 d观察组H-FABP水平均明显低于对照组(P<0.05)。随访3月发现观察组mRS得分低于对照组(P<0.05)。结论葛酮通络胶囊联合丁苯酞氯化钠注射液可以更明显改善LAA型急性脑梗死患者的神经功能损伤,更好地保护脑细胞,降低H-FABP水平。
Objective To investigate the curative effect of Puerarin Tongluo Capsule(葛酮通络胶囊)combined with bu⁃tylphthalide in the treatment of acute cerebral infarction of atherosclerotic type(LAA)and the effect on heart-type fatty acid binding protein(H-FABP).Methods One hundred and sixty-eight patients diagnosed as LAA-type of acute cerebral infarc⁃tion within 48 hours of onset were selected as the research subjects.The patients were divided into an observation group and a control group according to the random number method.The control group was given the conventional treatment and butylphthalide sodium chloride injection.The observation group was additionally given Puerarin Tongluo Capsule on the basis of the control group.Before treatment,neurological deficits were assessed by using the National Institutes of Health Stroke Scale(NIHSS)7 and 14 days after treatment.Fasting blood samples were collected before treatment,3 d,7 d and 14 d after treatment.H-FABP level was detected by ELISA.The modified Rankin scale(mRS)was used to evaluate the ability to live in three months of follow-up.Results The total effective rate of the observation group was 92.86%(78/84),which was higher than that(82.14%,69/84)of the control group(P<0.05).With the prolongation of treatment,the NIHSS score and H-FABP level of patients in the two groups showed an overall downward trend.On day 14 after treatment,the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05).And the levels of H-FABP in the observation group on the 3rd,7th and 14th day after treatment were significantly lower than those in the control group(P<0.05).Three months follow-up showed that the score of mRS in the observation group was lower than that in the control group(P<0.05).Conclusion Puerarin Tongluo Capsule combined with butylphthalide sodium chloride injection could more significantly improve the neurological impairment in patients with LAA-type of acute cerebral infarction,better protect brain cells and reduce the level of H-FABP.
作者
高永俊
畅雪丽
杜文贤
李晓峰
杨文明
赵文珺
杨文静
GAO Yongjun;CHANG Xueli;DU Wenxian;LI Xiaofeng;YANG Wenming;ZHAO Wenjun;YANG Wenjing(Department of Neurology,Jinzhong First People's Hospital,Jinzhong 030600,Shanxi,China;Department of Neurology,The First People's Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi,China;Department of Geriatrics,Linfen People's Hospital,Linfen 041000,Shanxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第2期124-127,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(82001222)。
关键词
葛酮通络胶囊
丁苯酞
大动脉粥样硬化型
急性脑梗死
心型脂肪酸结合蛋白
Puerarin Tongluo Capsule(葛酮通络胶囊)
butylphthalide
atherosclerotic type of aorta
acute cerebral infarc⁃tion
heart type fatty acid binding protein
