摘要
目的评价中国40岁以上中老年人群原发性闭角型青光眼(PACG)的患病率及相关影响因素。方法二次研究。检索PubMed、Embase、Web of Science、中国知网和万方数据库中2000至2022年基于中国人群PACG患病率的中、英文流行病学研究论文。2名研究者遵循纳入、排除标准独立完成文献检索、纳入、质量评估和数据提取, 产生的歧义与第3名研究者协商解决。计算I2值评估异质性, 使用相应效应模型进行效应合并和荟萃分析, 并进行亚组分析(性别、年龄、调查时间、居住区域、诊断标准、气温带)、敏感性分析和发表偏倚分析。结果纳入23篇文献, 其中8篇为高质量, 15篇为中质量。过去近20年中国40岁以上中老年人群PACG的总患病率为1.35%(95%置信区间:1.08%~1.61%);女性PACG患病率(1.40%)明显高于男性(0.96%, P<0.01);年龄与患病率呈正相关(P<0.01);城市(1.3%)与农村(1.2%)的患病率相似(P=0.61);诊断标准中必备视野或视神经损伤的文献合并得到的患病率(1.1%)低于非必备文献(1.7%, P<0.01);在年积温较低的中温带, PACG患病率更高(1.7%, P=0.02)。结论近20年中国40岁以上中老年人群的PACG患病率约为1.35%, 不同性别、年龄、地区间存在差异, 女性、高龄、寒冷地区人群的患病率更高。
Objective To evaluate the prevalence and relevant factors of primary angle-closure glaucoma(PACG)in the middle-aged and elderly(40 years old and above)Chinese population.Methods Epidemiological literature(of English and/or Chinese language)on prevalence of PACG in China between 2000 and 2022 were retrieved from PubMed,Embase,Web of Science,CNKI,and Wanfang database.Two researchers conducted the process of document retrieval,inclusion,quality assessment and data extraction independently based on inclusion and exclusion criteria.Disagreement was resolved by consensus with a third researcher.The heterogeneity among studies was assessed by using the I2 statistics,and a corresponding model was used for the meta-analysis.Subgroup analysis(gender,age,survey date,place of residence,diagnostic criteria,and temperature zone),as well as sensitivity analysis and publication bias analysis,were conducted.Results Twenty-three studies were included in this research.Among them,eight were of high-quality and fifteen were of middle-quality.In the past 20 years,the PACG prevalence in middle-aged and elderly(40 years and older)Chinese population was 1.35%(95%CI:1.08%to 1.61%).Chinese women(1.40%)were more likely to have PACG than men(0.96%,P<0.01).The PACG prevalence had a positive correlation with age(P<0.01).The prevalence was similar between urban(1.3%)and rural(1.2%,P=0.61)areas.The PACG prevalence from studies in which the diagnostic criteria of PACG requested the symptom of vision or optic nerve damage(1.1%)was lower than that those without such requirement(1.7%,P<0.01).In mid-temperate zone,the prevalence was higher(1.7%,P=0.02).Conclusions The PACG prevalence in middle-aged and elderly(40 years old and above)Chinese population was 1.35%in the last 20 years.The prevalence of PACG varies across age,regions,and other variations.This risk is higher in the elderly,women,and people in cold regions among Chinese population.
作者
陈瑾媛
黄文俏
李昊宇
卢尹悦
姚贻华
朱益华
梁远波
Chen Jinyuan;Huang Wenqiao;Li Haoyu;Lu Yinyue;Yao Yihua;Zhu Yihua;Liang Yuanbo(Department of Ophthalmology,The First Affiliated Hospital of Fujian Medical University,Fujian Institute of Ophthalmology,Fuzhou 350004,China;Eye Hospital of Liuzhou,Liuzhou Red Cross Hospital,Liuzhou 545001,China;Department of Ophthalmology,The Second Xiangya Hospital of Central South University,Changsha 410000,China;Department of Ophthalmology,Fujian Provincial Hospital,Fuzhou 350001,China;Eye Hospital of Wenzhou Medical University,National Clinical Research Center for Ocular Diseases,Wenzhou 325027,China)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2022年第11期896-906,共11页
Chinese Journal of Ophthalmology
基金
国家重点研发计划(2020YFC2008200)
福建省自然科学基金(2020J05251)
福建省卫健委科技计划(2021CXA021)
福建医科大学启航基金(2021QH2038)
浙江省万人计划科技创新领军人才(2021R52012)。
