摘要
目的:分析大理大学第一附属医院心力衰竭住院患者沙库巴曲缬沙坦的用药情况,为该药的临床合理应用提供参考。方法:利用医院信息系统收集2020年6—12月该院使用沙库巴曲缬沙坦的住院患者的基本情况,回顾性分析药物应用情况。结果:共纳入213例有适应证患者,其中存在相对用药禁忌证的有42例,起始剂量或用药频次不合理的有49例,靶剂量不达标的有173例;93例使用ACEI或ARB后转换为沙库巴曲缬沙坦,转换不合理的有28例;用药前后相比,无相对禁忌证患者心功能得到明显改善,而有相对禁忌证患者肾功能有较明显改善;49例发生药品不良反应。结论:该院心力衰竭患者使用沙库巴曲缬沙坦存在一些不合理情况,表现为存在相对用药禁忌证、初始给药剂量偏低、靶剂量达标率低、药物转换时机不适宜等,建议医疗机构规范该药的临床应用。
Objective:To analyze the application of sacubitril-valsartan in inpatients with heart failure in the First Affiliated Hospital of Dali University,so as to provide a basis for clinical rational use of the drug. Methods:The hospital information system was used to collect the basic information of inpatients who used sacubitril-valsartan from June to December 2020,and the application of the drug was retrospectively analyzed. Results:A total of 213 patients with indications were enrolled,and 42 cases had relative drug contraindications. The initial dose or frequency were unreasonable in 49 cases,and the target dose was not up to standard in 173 cases. There were 93 cases treated with ACEI or ARB converted to the application of sacubitril-valsartan,and 28 cases were not properly converted. Compared to the situation before treatment,the cardiac function of patients without relative contraindications improved significantly,while the renal function of patients with relative contraindications improved obviously. 49 cases had adverse drug reaction. Conclusion:There are some unreasonable situations in the use of sacubitril-valsartan in patients with heart failure in this hospital,such as relative medication contraindications,low initial dose,low rate of target dose reaches to standard,and inappropriate drug timing of drug conversion. It is suggested that medical institutions should standardize the clinical application of the drug.
作者
李秋镜
郭羽
赵燕菊
沈磊
Li Qiujing;Guo Yu;Zhao Yanju;Shen Lei(College of Pharmacy,Dali University,Dali,Yunnan 671000,China;Department of Pharmacy,The First Affiliated Hospital of Dali University,Dali,Yunnan 671000,China)
出处
《大理大学学报》
2022年第10期22-27,共6页
Journal of Dali University
基金
云南省基础研究计划项目(202101AT070030)。
