摘要
目的探究使用非奈利酮联合达格列净治疗2型糖尿病性肾病患者的效果。方法方便选取2023年3月—2025年3月云南省临沧市人民医院内分泌科收治的60例2型糖尿病性肾病患者,按治疗方法差异分为观察组(n=30)与对照组(n=30),分别行达格列净结合常规治疗与非奈利酮结合达格列净治疗。比较两组的肾功能、炎症指标、血糖指标、不良反应。结果治疗后,相较于对照组,观察组血尿素氮、血肌酐、糖化血红蛋白、尿白蛋白/肌酐比值、空腹血糖、C反应蛋白、餐后2 h血糖、白细胞介素-6、肿瘤坏死因子-α水平更低,差异均有统计学意义(P均<0.05)。不良反应发生率组间比较,差异无统计学意义(P>0.05)。结论非奈利酮联合达格列净治疗2型糖尿病性肾病的效果良好,利于改善蛋白尿、肾功能与炎症状态,且维持血糖平稳,安全性较好。
Objective To explore the effect of fenelidone combined with dapagliflozin in patients with type 2 diabetic nephropathy.Methods From March 2023 to March 2025,60 patients with type 2 diabetic nephropathy admitted to the Department of Endocrinology in Lincang People's Hospital of Yunnan Province were conveniently selected.They were divided into an observation group(n=30)and a control group(n=30)according to different treatment methods.The observation group was treated with dapagliflozin combined with conventional therapy,while the control group received finerenone combined with dapagliflozin.The renal function,inflammation index,blood glucose index and adverse reactions were compared between the two groups.Results After treatment,compared with the control group,the observation group showed significantly lower levels of blood urea nitrogen,serum creatinine,glycated hemoglobin A1c,urinary albumin-to-creatinine ratio,fasting plasma glucose,C-reactive protein,2-hour postprandial plasma glucose,interleukin-6,and tumor necrosis factor-α,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of type 2 diabetic nephropathy with non-nalidone combined with dapagliflozin has a good effect,which is conducive to improving proteinuria,renal function and inflammatory state,and maintaining stable blood glucose and good safety.
作者
杨子秀
范新强
陈煜娟
莫明翠
刘艳
朱丽娟
YANG Zixiu;FAN Xinqiang;CHEN Yujuan;MO Mingcui;LIU Yan;ZHU Lijuan(Department of Endocrinology,Lincang People's Hospital,Lincang 677000,Yunnan,China)
出处
《糖尿病新世界》
2025年第21期105-108,共4页
Diabetes New World
关键词
非奈利酮
达格列净
2型糖尿病肾病
疗效
安全性
Fenaridone
Dapagliflozin
Type 2 diabetic nephropathy
Therapeutic effect
Safety
