摘要
目的探讨经直肠多模态超声检查参数在前列腺癌内分泌治疗效果监测与评估中的价值。方法选取2019年11月至2021年5月内蒙古自治区人民医院经病理学证实的前列腺癌并接受内分泌疗法治疗的患者30例。检测记录内分泌治疗前、治疗后1个月、治疗后3个月血清前列腺特异性抗原(PSA)水平及前列腺体积、彩色多普勒参数、弹性指数、超声造影等定量参数,对治疗前后参数进行比较,各指标变化量与PSA的相关性采用Spearman相关分析。结果总前列腺特异性抗原、游离前列腺特异性抗原、前列腺体积在治疗前、治疗后1个月与治疗后3个月差异有统计学意义(均P<0.05),且随着治疗时间增加数值均呈现下降趋势;阻力指数在治疗前、治疗后1个月差异无统计学意义(P>0.05),治疗后3个月显著下降,差异有统计学意义(P<0.05);弹性指数、峰值强度、曲线下面积、梯度在治疗后1个月、治疗后3个月的数值低于治疗前,到达时间、上升时间在治疗后1个月、治疗后3个月的数值高于治疗前,差异有统计学意义(均P<0.05)。Spearman相关分析显示治疗前后各定量参数变化与PSA值变化无相关性(P>0.05)。结论前列腺体积、彩色多普勒参数、弹性指数、超声造影参数在前列腺癌内分泌治疗后早期发生变化,可作为临床前列腺癌疗效监测指标PSA的有益补充,用于临床前列腺癌内分泌治疗效果的评估。
Objective To explore the value of transrectal multimodal ultrasound parameters in monitoring and evaluating the efficacy of endocrine therapy for prostate cancer.Methods Thirty patients with prostate cancer confirmed by pathology and treated with endocrine therapy in Inner Mongolia Autonomous Region People′s Hospital from November 2019 to May 2021 were selected.The levels of serum prostate specific antigen(PSA),prostate volume,color Doppler parameters,elasticity index and contrast-enhanced ultrasound parameters were measured and recorded before treatment,1 month and 3 months after treatment.The parameters before and after treatment were statistically analyzed.The correlation between the changes of each index and PSA was analyzed by Spearman correlation analysis.Results Total prostate specific antigen,free prostate specific antigen,and prostate volume were significantly different before treatment,and 1 month and 3 months after treatment(P<0.05),and the values showed a downward trend with increase of treatment time.There was no significant difference in resistance index before and 1 month after treatment(P>0.05),but decreased significantly 3 months after treatment(P<0.05).The values of elasticity index,peak intensity,area under curve and gradient at 1 month and 3 months after treatment were lower than those before treatment,while the arrival time and rising time at 1 month and 3 months after treatment were significantly higher than those before treatment(P<0.05).Spearman correlation analysis showed that there was no correlation between the changes of quantitative parameters and PSA value before and after treatment(P>0.05).Conclusions Prostate volume,color Doppler parameters,elasticity index,and contrast-enhanced ultrasound parameters change in the early stage of endocrine therapy for prostate cancer,which can be used as a useful supplement to PSA for prostate cancer,and can be used to evaluate the efficacy of clinical prostate cancer endocrine therapy.
作者
刘倩
红华
梁丹艳
吴国柱
孙冉
王芳
孙跃
冯媛
Liu Qian;Hong Hua;Liang Danyan;Wu Guozhu;Sun Ran;Wang Fang;Sun Yue;Feng Yuan(Department of Ultrasound,Inner Mongolia Autonomous Region People′s Hospital,Hohhot 010017,China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2022年第9期802-808,共7页
Chinese Journal of Ultrasonography
基金
内蒙古自治区关键技术攻关计划项目(2019GG096,2019GG101)
内蒙古自治区人民医院院内基金项目(2019YN20)。
关键词
超声检查
经直肠
前列腺癌
内分泌治疗
超声造影
弹性成像
Ultrasonography,transrectal
Prostate cancer
Endocrine therapy
Contrast-enhanced ultrasound
Elastography
