摘要
目的探讨内分泌治疗前后前列腺外周带癌区和非癌区的ADC值的变化情况,并比较不同b值时ADC值之间的差异。方法使用EPI扫描序列,对经手术病理或穿刺活检证实的14例前列腺癌和18例内分泌治疗6个月以上的前列腺癌患者行磁共振扩散加权检查,b值分别为300,500,800s/mm2。依病理结果,将前列腺六分区归类为癌区和非癌区,测量每个分区的ADC值,同时测量每位患者膀胱、闭孔内肌的ADC值。结果在三个不同的b值时,均获得了前列腺外周带癌区、非癌区、膀胱、闭孔内肌的ADC值。内分泌治疗后,不同b值癌区的ADC值均有升高,非癌区的ADC值(b值为500,300s/mm2)出现不同程度的降低,b值为800s/mm2时,ADC值变化不大;对照组和治疗组不同b值之间外周带癌区、非癌区、膀胱和闭孔内肌的ADC值间均有统计学差异。结论内分泌治疗后前列腺外周带癌区和非癌区的ADC值改变不同,不同b值所测得的前列腺外周带癌区、非癌区、膀胱和闭孔内肌的ADC值有差异,ADC值用于判断前列腺癌内分泌治疗效果是可行的。
Objective To assess the changes of the apparent diffusion coefficient （ADC） values of the cancerous and noncancerous regions of prostate peripheral zone in patients confirmed with prostate cancer with endocrine therapy. Methods Diffusion-weighted echo-planar imaging （EPI） sequences with different b values were performed in 32 patients with evidence of prostate cancer, including 18 patients treated with endocrine therapy over 6 months and 14 nontreated matched patients as controls. The apparent diffusion coefficients （ADCs） were calculated from different diffusion-weighted imaging using different b values. According to the pathological results obtained by ultrasound guided systemic biopsy, the locations of the prostate cancerous region were marked as one or more of the sextants. Results Acceptable images for ADC measurement were obtained in all cases of different sequences. Compared with the mean ADC values in nontreated patients, mean values of endocrine treated patients increased in cancerous regions when b was 800,500 or 300 s/mm^2 and decreased in noncancerous regions when b was 500 or 300 s/mm^2 and didn＇t vary statistically with b value being 800 s/mm^2. Under different b values, there was statistically difference of mean ADC values in the cancerous and noncancerous regions of prostate peripheral zone, bladder and the obturator internus between the treated and control patients. Conclusion The values of ADCs vary differently in cancerous and noncancerous regions. There was statistically difference of mean ADC values with different b values in the cancerous and noncancerous regions of prostate peripheral zone, bladder and the obturator internus between the treated and control patients. Measurement of ADCs might be useful to evaluate the efficacy of endocrine therapy for patients with prostate cancer.
出处
《中国医学影像技术》
CSCD
北大核心
2007年第5期758-761,共4页
Chinese Journal of Medical Imaging Technology
关键词
前列腺肿瘤
磁共振成像
内分泌治疗
扩散加权成像
表观扩散系数
Prostatic neoplasms
Magnetic resonance imaging
Endocrine therapy
Diffusion weighted imaging
Apparent diffusion coefficient
