摘要
气道重塑是哮喘致死的关键因素,一旦形成,难以逆转。基于转化生长因子-β1(transforming growth factor-β1,TGF-β1)/Smads信号通路与哮喘气道重塑的密切关系,既往研究已初步表明针刺通过调控TGF-β1/Smads信号通路实现抑制气道重塑的发展进程。本文从指标检测、研究方案、取穴标准、针刺时机4个方面对针刺调控TGF-β1/Smads信号通路干预气道重塑的实验研究进行分析并得出解决方案,为今后研究工作提供参考。
Airway remodeling is a key factor in death from asthma,and once formed,it is difficult to reverse.Based on the close relationship between the transforming growth factor-β1(TGF-β1)/Smads signaling pathway and airway remodeling in asthma,the previous studies have preliminarily shown that acupuncture suppresses the developmental progression of airway remodeling by regulating the TGF-β1/Smads signaling pathway.In this paper,the experimental research on the intervention of acupuncture on TGF-β1/Smads signaling pathway in airway remodeling was analyzed and solutions were produced from four aspects:indicator detection,research scheme,acupoint selection standard and acupuncture timing,aiming to provide reference for the future research.
作者
张倩
乔赟
时宜蓉
ZHANG Qian;QIAO Yun;SHI Yirong(College of Acupuncture-Moxibustion and Tuina,Guangxi University of Chinese Medicine,Nanning,Guangxi 530200,China)
出处
《湖南中医药大学学报》
CAS
2022年第9期1570-1573,共4页
Journal of Hunan University of Chinese Medicine
基金
广西自然科学基金面上项目(2017GXNSFAA198201,2020GXNSFAA297021)。
