摘要
目的观察以伏风理论治疗咳嗽变异型哮喘(CVA)的临床疗效,及其对气道高反应性和抗炎效果的影响。方法将120例患者随机分为2组,每组60例。治疗组以伏风理论拟定的协定基础方加味治疗,对照组以舒氟美口服治疗。比较2组症状积分、第1秒最大用力呼气量(FEV1)、最大呼气流速(PEF)、用力肺活量(FVC)、外周血嗜酸性粒细胞(EOS)计数以及细胞免疫功能IgE等,并比较其临床疗效。结果治疗组症状总积分为(5.00±4.23)分,明显低于对照组(7.19±6.04)分,差异有统计学意义(P<0.05);治疗组肺功能改善情况较对照组明显,差异有统计学意义(P<0.05或P<0.01);治疗组外周血EOS、IgE下降均较对照组明显,差异有统计学意义(P<0.05)。治疗组临床总有效率(80.5%)明显高于对照组(72.2%),差异有统计学意义(P<0.05)。结论以伏风理论治疗CVA疗效显著。
Objective To observe the clinical efficacy of latent-wind theory for treatment of cough variant asthma （CVA） and its influences on airway hyperresponsiveness and anti-inflammatory effect. Methods One hundred and twenty cases were randomly divided into two groups, sixty cases in each one. The treatment group was treated with conventional basic prescription based on latent-wind theory, while the control group was treated with oral administration of theophylline. The symptom scores as well as FEV1, PEF, FVC, EOS and IgE in two groups were compared, also its clinical efficacy was observed. Results The total score of symptom was （5.00 ±4. 23） in the treatment group, which was significantly lower than （7. 19 ±6. 04） in the control group （P 〈0. 05）. The improvement of lung function in the treatment group was superior to that in the control group （P 〈0. 05）. Compared with the control group, the EOS and IgE were obviously reduced in the treatment group （P 〈 0. 05）. The clinical total effective rate was 80. 5% in the treatment group, which was significantly higher than 72. 2% in the control group （P 〈 0. 05）. Condusion The latent-wind theory is effective for treatment of cough variant asthma.
出处
《北京中医药》
2014年第1期3-5,共3页
Beijing Journal of Traditional Chinese Medicine
基金
2011年广东省中医药管理局资助项目(20112159)
关键词
咳嗽变异型哮喘
气道高反应性
慢性炎症
伏风理论
cough variant asthma
airway hyperresponsiveness
chronic inflammation
latent-wind theory
