摘要
目的:探讨2型糖尿病(T2DM)患者幽门螺旋杆菌(Hp)感染与糖尿病肾病(DN)之间的相关性。方法:选择宣城市人民医院内分泌科2017年8月~2020年5月住院的T2DM患者506例。依据尿白蛋白/肌酐比值(UACR)分为3组,即正常组263例、早期糖尿病肾病(DN1)组141例、临床蛋白尿(DN2)组102例。结果:DN1、DN2组患者Hp感染率(39.7%、40.2%)均高于正常组(24.7%)(P<0.05)。校正血肌酐、血尿素氮、空腹血糖、尿酸、胰岛素抵抗指数、收缩压和舒张压因素进行多因素Logistic回归显示,Hp感染(OR=2.246,95%CI:1.506~3.351)是T2DM患者发生DN风险的危险因素(P<0.05)。结论:Hp感染会提高T2DM患者DN的发生风险。
Objective:To investigate the relationship between Helicobacter pylorus(Hp) infection and diabetic nephropathy in patients with of type 2 diabetes(T2 DM).Methods:506 patients with T2 DM treated in the Department of Endocrinology, Xuancheng People′s Hospital were included from August 2017 to May 2020,and divided into normal group(n=263),early diabetic nephropathy group(DN1 group, n=141) and clinical proteinuria group(DN2 group, n=102) according to urinary albumin to creatine ratio(UACR).Results:Hp infection rate was higher in DN1(39.7%) and DN2(40.2%) group than in control group(24.7%)(P<0.05).Multivariate Logistic regression analysis after adjusting the levels of serum creatinine, blood urea nitrogen, fasting blood glucose and uric acid as well as insulin resistance index, systolic blood pressure and diastolic blood pressure showed that Hp infection(OR=2.246,95%CI:1.506-3.351) was a risk factor for diabetic nephropathy in patients with T2 DM(P<0.05).Conclusion:Hp infection can increase the risk of diabetic nephropathy in patients with type 2 diabetes.
作者
王思宏
黄崇兵
倪孝兵
张卫星
宋全超
何春玲
WANG Sihong;HUANG Chongbing;NI Xiaobing;ZHANG Weixing;SONG Quanchao;HE Chunling(Department of Endocrinology,Xuancheng People′s Hospital,Xuancheng 242000,China)
出处
《皖南医学院学报》
CAS
2022年第4期344-347,共4页
Journal of Wannan Medical College
基金
安徽省高等学校人文社会科学研究项目(SK2019A0214)。
