摘要
心力衰竭(简称心衰)是心系疾病发展的终末阶段,具有较高的病死率和再住院率。现代研究表明,能量代谢障碍伴随本病发展始终,氧化应激损伤、脂毒性、炎性介质生成等病理表现与中医学对心衰的认识相似。中医学认为心衰发病始于心气虚,心力内乏,乏久必竭,累及肾脏,气化、水液运行障碍,导致痰饮、瘀毒病理产物瘀结,形成恶性循环。心肾之阳气与心肌能量利用、代谢、转运功能密切相关。因此,心肾功能相互协调对于机体内环境稳定尤为重要。“心肾相交”理论广泛应用于心衰的临床防治中,笔者以肾主纳气为切入点,探讨益气温阳法调节心肌能量代谢机制在心衰中的防治作用。
Heart failure(HF)is the terminal stage of the development of cardiac diseases,with high mortality and rehospitalization rates.Modern research has shown that energy metabolism disorders accompany the development of diseases,and the pathological manifestations such as oxidative stress injury,lipotoxicity,and inflammatory mediator generation are similar to the understanding of HF in Chinese Medicine(CM).CM believes that HF starting from a deficiency of Xin qi,which leads to a lack of internal energy,which will inevitably lead to exhaustion after a long period of exhaustion.It affects the function of the Shen,and impedes the movement of qi and water,resulting in the formation of a vicious circle of pathological products of phlegm,stasis and toxin.The yang qi of the Xin and Shen is closely related to the function of myocardial energy utilization,metabolism and transport.Therefore,the coordination of Xin and Shen functions is particularly important to the stability of the body’s internal environment.The theory of"Xin-Shen intersection"is widely used in the clinical prevention and treatment of HF.In this paper,the Shen dominating qi was taken as the breakthrough point to explore the prevention and treatment effect of the method of nourishing qi and yang regulating myocardial energy metabolism for HF.
作者
邓艳萍
史胜楠
吴小平
马玲
王培利
DENG Yan-ping;SHI Sheng-nan;WU Xiao-ping;MA Ling;WANG Pei-li(Graduate School of Beijing University of Chinese Medicine,Beijing 100029;Cardiovascular Center of Xiyuan Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100091;Graduate School of China Academy of Chinese Medical Science,Beijing 100700)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2022年第6期740-743,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81973681)
第四批全国中医(临床、基础)优秀人才研修项目(No.国中医药人教发[2017]24号)。
关键词
心力衰竭
能量代谢障碍
肾主纳气
益气温阳
heart failure
energy metabolism disorders
Shen dominating qi
invigorating qi and warming yang
