摘要
目的:分析同型半胱氨酸(Hcy)联合妊娠相关蛋白(PAPP-A)、人绒毛膜促性腺激素(HCG)水平对妊娠早期流产治疗结局的预测价值。方法:回顾性分析2018年7月-2020年6月本院收治的135例妊娠早期先兆流产孕妇临床资料,根据妊娠结局分为继续妊娠组(72例)和难免流产组(63例),产前检查正常妊娠孕妇60例为对照组,对比3组血清Hcy、PAPP-A、HCG水平并分析对妊娠早期流产结局的预测价值。结果:难免流产组、继续妊娠组、对照组血清Hcy水平依次降低,血清PAPP-A、HCG水平依次升高(均P<0.05)。血清Hcy、PAPP-A、HCG联合检测预测先兆流产发生难免流产的cutt off值分别为7.59μmol/L、6.38ng/ml、12561.82U/L,此时敏感度(87.3%)、特异度(93.1%)、准确度(90.4%)、阳性预测值(91.7%)和阴性预测值(89.3%)均较高。结论:血清Hcy、PAPP-A、HCG联合检测可以预测妊娠早期流产治疗结局。
Objective:To analyze the value of the homocysteine(Hcy)level combined with the levels of pregnancy-associated plasma protein-A(PAPP-A)and human chorionic gonadotropin(HCG)for predicting the treatment outcomes of women with early threatened abortion.Methods:The clinical data of 135pregnant women with early threatened abortion from July 2018to June 2020were analyzed retrospectively.According to the pregnancy outcomes,these women were divided into group A(72cases with continued pregnancy)and group B(63cases with inevitable abortion),and 60normal pregnant women with regularly prenatal examination were selected in group C.The levels of serum Hcy,PAPP-A,and HCG of the women were compared among the three groups.The predictive value of the levels of serum Hcy,PAPP-A,and HCG for the outcomes of early threatened abortion after treatment was analyzed.Results:The level of serum Hcy of the women in group B,group A,and group C had decreased gradually,while the levels of serum PAPP-A and HCG of the women in group B,group A,and group C had increased gradually(all P<0.05).The cut off values of serum Hcy level,PAPP-A level,and HCG level for predicting the inevitable abortion of the women with threatened abortion were 7.59μmol/l,6.38ng/ml,and 12561.82U/l,respectively.The sensitivity(87.3%),the specificity(93.1%),the accuracy(90.4%),the positive predictive value(91.7%),and the negative predictive value(89.3%)of the combined detections of serum Hcy,PAPP-A,and HCG levels for predicting the inevitable abortion were all higher.Conclusion:the combined detection of serum Hcy,PAPP-A,and HCG levels of women with early threatened abortion can be used to predict their outcomes after treatment.
作者
吴熠
邓强
胡凌云
WU Yi;DENG Qiang;HU Lingyun(Guang'an People's Hospital,Guang'an,Sichuan Province,638000)
出处
《中国计划生育学杂志》
2022年第4期907-910,共4页
Chinese Journal of Family Planning
关键词
先兆流产
难免流产
同型半胱氨酸
妊娠相关蛋白
人绒毛膜促性腺激素
预测价值
Threatened abortion
Inevitable abortion
Homocysteine
Pregnancy-associated protein
Human chorionic gonadotropin
Predictive value
