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解整合素金属蛋白酶12分泌型在筛查孕中期18-三体综合征胎儿中的应用 被引量：3

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摘要 目的探讨解整合素金属蛋白酶12分泌型(ADAM12-S)在筛查孕中期18-三体综合征胎儿的应用。方法以孕育18-三体综合征胎儿的孕中期孕妇7例作为病例组,正常妊娠孕妇621例为对照组,检测血清ADAM12-S水平并比较不同筛查方案对18-三体综合征胎儿的筛查效率。结果对照组血清ADAM12-S水平与孕周呈正相关(r=0.388,P<0.01),其中位数倍数与体重呈负相关(r=-0.201,P<0.01),与病例组比较无统计学差异(Z=1.32,P>0.05)。在特异性为95%时,ADAM12-S单独筛查18-三体综合征时的敏感性为14.3%,三联筛查方案(ADAM12-S+AFP+freeβ-hCG)与二联筛查方案(AFP+freeβ-hCG)在特异性为90%、95%、97%、99%时均具有相同的敏感性。结论 ADAM12-S单独筛查18-三体综合征胎儿的敏感性较低,三联筛查方案不能提高敏感性。
作者 张晓娟 蒋涛 孙云 吕伶
机构地区 南京医科大学附属南京妇幼保健院产前诊断中心
出处 《临床检验杂志》 CAS CSCD 北大核心 2012年第5期331-333,共3页 Chinese Journal of Clinical Laboratory Science
基金 南京市医学科技发展基金项目(ZKX08001) 南京市医学面上科技发展基金项目(2010NJMU028)
关键词 解整合素金属蛋白酶12分泌型 18-三体综合征 产前筛查
分类号 R714.55 [医药卫生—妇产科学]
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参考文献11

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同被引文献30

  • 1李治国.孕酮及PAPP-A在先兆流产预测中的应用[J].中国优生与遗传杂志,2006,14(11):72-72. 被引量：10
  • 2崔洪艳.妊娠11-13“周胎儿染色体非整倍体异常产前筛查与诊断策略[D].天津医科大学,2013.
  • 3戚红.解整合素-金属蛋白酶12作为产前筛查标志物的初步研究[D].北京协和医院,2008.
  • 4王民.解整合素金属蛋白酶12在产前诊断唐氏综合征中应用的研究[D].浙江大学,2011.
  • 5ACOG Praetice Bulletin No. 77: screening for fetal chromosomal ahnormalities[J]. Obstet Gynecol, 2007, 109 (1) : 217-227.
  • 6Kagan KO, Wright D, Baker A, et al. Screening for trisomy 21 hy maternal age, fetal nuchal translucency thickness, free beta- human ehorionic gonadotropin and pregnancy-associated plasma protein-A[J]. Ultrasound Obstet Gynecol, 2008, 31 (6): 618- 624.
  • 7Leung TY, Spencer K, Leung TN, et al. Higher median levels of free beta-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group, Implication for first trimester combined screening for Down's syndrome in the Chinese population[J]. Fetal Diaon Thor. 2006. 21(1). 14(1-143.
  • 8Brambati B, Macintosh MC, Teisner B, et al. Low maternal serum levels of pregnancy associated plasma protein A (PAPP-A) in the first trimester in association with abnormal fetal karyotype [J]. BrJ Obstet Gynaeeol, 1993, 100(4): 324-326.
  • 9Laigaard J, Sφrensen T, Frehlich C, et al. ADAMI2: a novel first-trimester maternal serum marker for Down syndrome [J]. Prenat Diagn, 2003, 23(13): 1086-1091.
  • 10Christiansen M, Pihl K, Hedley PL, etal. ADAM12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome[J]. Prenat Diagn, 2010, 30 (2), 110-114.

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临床检验杂志
2012年 第5期

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