摘要
目的探究孕早期孕妇血清可溶性人白细胞抗原G(sHLA-G)、抑制素A水平在预测先兆流产中的应用价值。方法采用回顾性研究方案,对象选取为2017年3月至2020年11月之间的114例保胎治疗的先兆流产患者,其中流产51例设为流产组,其余63例继续妊娠的患者则分为妊娠组,对比两组患者在孕6~10周的血清sHLA-G、抑制素A水平情况。结果在孕6周到孕10周期间,两组患者的血清sHLA-G水平均呈现下降趋势,流产组患者的血清抑制素A水平也呈现下降趋势,而不同于妊娠组患者的血清抑制素A却呈现上升趋势,各组数据均有统计学意义(P<0.05);在孕6-10周期间组间对比结果显示,流产组在孕6~9周的血清sHLA-G水平均显著低于妊娠组(P<0.05),流产组在孕6-9周血清抑制素A水平均显著低于妊娠组(P<0.05)。结论先兆流产患者的血清sHLA-G、抑制素A水平动态变化情况在一定程度上反映了患者的先兆流产结局,应当作为孕早期的相关指标检测并进行临床干预。
Objective To study the clinical value of the soluble human leukocyte antigen(sHLA-G)and the inhibin A in predicting the outcome of threatened abortion.Methods A retrospective study protocol was used,a total of 114 patients with threatened abortion admitted in our hospital from March 2017 to November 2020 were selected as the research objects.Among them,51 cases of abortion were divided into abortion group,and the remaining 63 cases of continued pregnancy were divided into pregnancy group.The levels of serum sHLA-G and inhibin A were compared between the two groups at 6~10 weeks of pregnancy.Results Between 6-10 gestation weeks,the sHLA-G levels of the two groups showed an decreased trend decreased,and the inhibin A level of the abortion group was on the decline,and the inhibin A level of the normal group appeared a rising trend with statistically significant differences(P<0.05).The comparison results between the groups at 6~10 weeks showed that the sHLA-G levels of the abortion group at 6-9 weeks of gestation were significantly lower than the normal group(P<0.05),the inhibin A levels of the abortion group at 6-9 weeks of gestation were also significantly lower than the normal group(P<0.05).Conclusion The dynamic changes of serum sHLA-G and inhibin A levels in patients with threatened abortion reflect the outcome of threatened abortion to a certain extent,and they should be used as a relevant index of early pregnancy and carry out corresponding clinical intervention.
作者
余慧丽
YU Huili(Department of Obstetrics,Sui County Maternity and Child Healthcare Hospital,Shangqiu Henan 476900,China)
出处
《临床研究》
2022年第4期131-134,共4页
Clinical Research
关键词
先兆流产
孕早期
可溶性人白细胞抗原G
抑制素A
threatened abortion
early pregnancy
soluble human leukocyte antigen G
inhibin A
