摘要
目的探讨老年冠心病患者血尿酸、血脂水平与其肠道菌群分布情况的关系。方法选取2018年3月至2019年8月我院收治的老年冠心病患者120例为研究组,选取同期在我院进行体检的健康志愿者120名为对照组。检测比较两组研究对象的血尿酸水平、血脂水平、肠道菌群分布情况;对老年冠心病患者的血尿酸、血脂水平与其肠道菌群数量的关系进行Pearson相关分析。结果研究组患者的血尿酸(BUA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显高于对照组健康者,高密度脂蛋白胆固醇(HDL-C)水平明显低于对照组健康者,差异有统计学意义(P<0.05)。研究组患者粪便中的双歧杆菌、乳酸杆菌、拟杆菌数量明显少于对照组健康者,大肠杆菌、梭菌、链球菌数量明显多于对照组健康者,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,研究组患者的BUA水平与其粪便中的双歧杆菌、乳酸杆菌数量呈负相关,与其粪便中的大肠杆菌数量呈正相关;TG水平与其粪便中的大肠杆菌、梭菌数量呈正相关,与其粪便中的双歧杆菌、乳酸杆菌、拟杆菌数量呈负相关;HDL-C水平与其粪便中的梭菌、链球菌数量呈正相关;LDL-C水平与其粪便中的双歧杆菌、梭菌、链球菌数量呈负相关;TC水平与其粪便中的大肠杆菌数量呈正相关,与其粪便中的双歧杆菌、乳酸杆菌数量呈负相关。结论老年冠心病患者的血脂、血尿酸水平增高与其肠道菌群分布异常有关,肠道菌群可能对患者的血脂水平有重要的影响。
Objective To explore the relationship between blood uric acid,blood lipid levels and the distribution of intestinal flora in elderly patients with coronary heart disease.Method A total of 120 elderly patients with coronary heart disease admitted to our hospital from March 2018 to August 2019 were selected as the study group,and 120 healthy volunteers who underwent physical examination in our hospital in the same period were selected as the control group.The levels of serum uric acid,blood lipid and the distribution of intestinal flora were measured and compared between the two groups.Pearson correlation analysis was performed on the relationship between the levels of blood uric acid,blood lipid and the number of intestinal flora in elderly patients with coronary heart disease.Results The patients in the study group obtained higher levels of blood uric acid(BUA),total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C),whereas a lower level of high density lipoprotein cholesterol(HDL-C)as compared with the healthy volunteers in the control group,with statistically significant differences(P<0.05).The excrement from the patients in the study group yielded less number of Bifidobacteria,Lactobacillus and Bacteroides,whereas more number of Escherichia coli,Clostridium and Streptococcus in comparison with the excrement from the healthy volunteers in the control group,with statistically significant differences(P<0.05).Pearson correlation analysis results showed that the level of BUA was negatively correlated with the number of Bifidobacteria and Lactobacillus in the excrement from the study group,and positively correlated with the number of Escherichia coli.The TG level of patients was positively correlated with the number of Escherichia coli and Clostridium in the excrement from the study group,and negatively correlated with the number of Bifidobacteria,Lactobacillus and Bacteroides.The level of HDL-C was positively correlated with the number of Clostridium and Streptococcus in the excrement from the study group.The level of LDL-C was negatively correlated with the number of Bifidobacteria,Clostridium and Streptococcus in the excrement from the study group.The TC level of patients was positively correlated with the number of Escherichia coli,and negatively correlated with the number of Bifidobacteria and Lactobacillus in the excrement from the study group.Conclusion The increase of blood lipid and uric acid levels in elderly patients with coronary heart disease is related to the abnormal distribution of intestinal flora,which may have an important influence on the blood lipid level of patients.
作者
郭晓亮
李俊艳
袁宇
GUO Xiaoliang;LI Junyan;YUAN Yu(Coronary Heart Disease Intensive Care Unit,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,Henan Province,China)
出处
《内科》
2021年第5期593-595,615,共4页
Internal Medicine
基金
新乡市科技攻关计划项目(CXGG16012)。
关键词
老年冠心病患者
血尿酸
血脂
肠道菌群
Elderly patients with coronary heart disease
Blood uric acid
Blood lipid
Intestinal flora
