摘要
目的分析血清尿酸水平与老年冠心病易感风险因素的相关性。方法回顾性采集2017年1月至2019年1月我医院老年冠心病患者200例(冠心病组)和同期医院门诊接诊的非冠心病老年患者150例(对照组)的临床资料。患者入院后即刻采集外周静脉血,测定血清尿酸水平;并记录各基线资料情况,将冠心病可能的易感风险因素纳入,经单因素与多因素分析找出风险因素,分析血清尿酸水平与老年冠心病患者各易感风险因素的相关性。结果初步单因素分析发现,吸烟、合并糖尿病、低高密度脂蛋白胆固醇(HDL-C)血症、冠心病家族史、肾小球滤过率等均可能是老年冠心病患者易感风险因素(χ^2=6.739、15.655、6.331、9.615、23.279,P均<0.05);多因素分析证实,吸烟、合并糖尿病、低HDL-C血症、冠心病家族史、肾小球滤过率均是老年冠心病易感风险因素(OR=1.777、2.381、1.883、1.967、3.205,均P<0.05);吸烟、合并糖尿病、低HDL-C血症、有冠心病家族史、肾小球滤过率<100 ml/min的老年冠心病患者,其血清尿酸水平均高于其他患者(t=8.017、5.907、8.509、7.164、13.839,均P<0.001);经Spearman相关性分析检验证实,血清尿酸水平与老年冠心病患者吸烟、合并糖尿病、冠心病家族史等易感风险因素均呈正相关(r=0.409、0.422、0.422,均P<0.001),与低HDL-C血症、肾小球滤过率呈负相关(r=-0.428、-0.481,均P<0.001)。结论血清高尿酸水平与吸烟、糖尿病等诸多冠心病易感风险因素有紧密联系,可能是冠心病发病的独立危险因素。
Objective To examine potential predisposing risk factors for coronary heart disease(CHD)in elderly patients and the correlation between serum uric acid levels and the predisposing risk factors in elderly patients with CHD.Methods Clinical data of 200 elderly inpatients with CHD(CHD group)and 150 elderly outpatients without CHD(control group)at our hospital from January 2017 to January 2019 were retrospectively analyzed.Peripheral venous blood was collected from patients immediately after admission,and serum uric acid levels were measured.Baseline information of patients was recorded.Potential predisposing risk factors of CHD were identified by single-factor and multiple-factor analysis,and serum uric acid levels were compared against predisposing risk factors.The correlation between serum uric acid levels and predisposing risk factors in elderly patients with CHD was analyzed.Results According to preliminary single-factor analysis,smoking,diabetes mellitus,low high-density lipoprotein cholesterol(HDL-C)hypolipidemia,family history of CHD and glomerular filtration rate seemed to be predisposing risk factors for elderly patients with CHD(χ^2=6.739,15.655,6.331,9.615,23.279,P<0.05).Multiple-factor analysis showed that smoking,diabetes mellitus,low HDL-C hypolipidemia,family history of CHD and glomerular filtration rate were predisposing risk factors for elderly patients with CHD(OR=1.777,2.381,1.883,1.967,3.205,all P<0.05).Serum uric acid levels in elderly CHD patients with smoking,diabetes mellitus,low HDL-C hypolipidemia,family history of CHD or glomerular filtration rate<100 ml/min were higher than in patients without any of those conditions,and the difference was statistically significant(t=8.017,5.907,8.509,7.164,13.839,P<0.001).Spearman correlation analysis showed that serum uric acid levels were positively correlated with risk factors such as smoking,diabetes mellitus,and family history of CHD in elderly patients with CHD(r=0.409,0.422,0.422,all P<0.001),and were negatively correlated with low HDL-C hypolipidemia and glomerular filtration rate(r=-0.428 and-0.481,all P<0.001).Conclusions High level serum uric acid is closely related to many CHD risk factors such as smoking and diabetes mellitus and may be an independent risk factor for the onset of CHD.
作者
苏健康
朱开权
李路
Su Jiankang;Zhu Kaiquan;Li Lu(Intensive Cardiac Care Unit,the First People's Hospital of Shangqiu,Shangqiu 476100,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2020年第3期282-286,共5页
Chinese Journal of Geriatrics
关键词
冠状动脉疾病
尿酸
疾病易感性
相关性
Coronary heart disease
Uric acid
Disease susceptibility
Correlation
