摘要
目的探讨在心律失常治疗中采用胺碘酮联合美托洛尔的临床效果。方法68例心律失常患者,按照随机抽签法分为对照组和观察组,各34例。对照组患者采用单独胺碘酮片进行口服治疗,观察组患者在对照组基础上联合酒石酸美托洛尔片进行口服治疗。对比两组患者的心功能指标[心输出量(CO)、左心室射血分数(LVEF)、二尖瓣口舒张早期最大充盈速度与晚期最大充盈速度比值(E/A)],心律失常发作频率以及持续时间,血压水平,不良反应发生情况。结果治疗后,观察组患者的CO、LVEF、E/A水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的心律失常发作频率以及持续时间分别为(3.01±0.36)次/周、(4.52±0.63)min/次,均低于对照组的(4.84±0.57)次/周、(6.75±0.79)min/次,差异有统计学意义(P<0.05)。治疗后,观察组患者的舒张压和收缩压水平分别为(76.43±10.21)、(102.25±10.46)mm Hg(1 mm Hg=0.133 kPa),均低于对照组的(87.59±11.47)、(127.68±11.06)mm Hg,差异有统计学意义(P<0.05)。治疗后,观察组患者的不良反应发生率为5.88%(2/34),低于对照组的23.53%(8/34),差异具有统计学意义(P<0.05)。结论在心律失常的治疗过程中,采用胺碘酮联合美托洛尔治疗具有较好的临床效果,能够显著改善患者的心功能情况以及血压水平,降低患者的心律失常发作频率、持续时间以及不良反应发生率,值得临床研究和应用。
Objective To discuss the clinical effect of amiodarone combined with metoprolol in the treatment of arrhythmia.Methods A total of 68 patients with arrhythmia were randomly divided into control group and observation group,with 34 cases in each group.Patients in the control group were treated orally with amiodarone tablets alone,and patients in the observation group were treated orally with metoprolol tartrate tablets on basis of the control group.Patients in both groups were compared in terms of cardiac function indicators[cardiac output(CO),left ventricular ejection fraction(LVEF),peak mitral flow velocity in early diastole to that during atrial contraction(E/A)],frequency and duration of arrhythmia attacks,blood pressure level,occurrence of adverse reactions.Results After treatment,CO,LVEF,and E/A levels of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the frequency and duration of arrhythmia in the observation group were(3.01±0.36)times/week and(4.52±0.63)min/time,which were lower than(4.84±0.57)times/week and(6.75±0.79)min/time in the control group,and the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure and systolic blood pressure levels of the observation group were(76.43±10.21)and(102.25±10.46)mm Hg(1 mm Hg=0.133 kPa),which were lower than(87.59±11.47)and(127.68±11.06)mm Hg of the control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of adverse reactions in the observation group was 5.88%(2/34),which was lower than 23.53%(8/34)in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of amiodarone and metoprolol has good clinical effect on the treatment of arrhythmia,and it can significantly improve the heart function and blood pressure level of patients,reduce the frequency and duration of arrhythmia,and lower the incidence of adverse reactions of patients,which is worthy of clinical research and application.
作者
张丽萍
ZHANG Li-ping(Department of Internal Medicine,Traditional Chinese Medicine Hospital of Xifeng County,Tieling 112499,China)
出处
《中国实用医药》
2021年第29期115-117,共3页
China Practical Medicine
