摘要
咖啡酸及其衍生物在自然界中含量丰富,广泛存在于多种生物活性分子中,是一类具有广阔应用前景的天然活性成分。在咖啡酸及其衍生物可能修饰的结构中,通过增加或取代不同基团等方法将其转化成酯、酰胺以及多聚体等可得到具有不同生物活性的新衍生物,测定这些新衍生物的药理活性与其母体化合物的活性进行比较,以揭示有益的构效关系。论文概述了咖啡酸及其衍生物的药理活性,包括关于这些化合物的抗炎、抗癌和抗病毒活性的最新报道,介绍了多种构效关系,旨在为不断发掘能使咖啡酸及其衍生物活性增强的构效关系提供理论依据,进而特异性地开发新型的具有更强生物活性的咖啡酸衍生物。
Caffeic acid and its derivatives are abundant in nature and widely used in many kinds of biological active molecules.They are a kind of natural active ingredients with broad application prospects,The structures of the caffeic acid and its derivatives may be modified by adding or replacing different groups and converted them into other esters,amides and polymer-new derivatives with different biological activities.The determinations of these new derivatives of pharmacological activities instead of comparing the activity of the parent compound may reveal the beneficial structure-activity relationship.The pharmacological activities of caffeic acid and its derivatives were summarized in this paper,including anti-inflammatory,anticancer and antiviral activities of these compounds in the latest reports.A variety of structure-activity relationships were introduced for discovering the caffeic acid and its derivatives activity and providing theoretical basis for further study,and then exploiting specific new caffeic acid derivatives with stronger biological activity.
作者
张雯
孙雅丽
王琳
秦翠平
马建章
ZHANG Wen;SUN Ya-li;WANG Lin;QIN Cui-ping;MA Jian-zhang(College of Wildlife and Protected Area,Northeast Forestry University,Harbin,Heilongjiang,150040,China)
出处
《动物医学进展》
北大核心
2021年第8期103-106,共4页
Progress In Veterinary Medicine
基金
中央高校基本科研业务费(2572020BE04)
国家自然科学基金项目(31602120)
黑龙江省自然科学基金项目(C2016003)。
关键词
咖啡酸
衍生物
药理活性
构效关系
caffeic acid
derivative
pharmacological activity
structure-activity relationship
