摘要
目的:分析91例不明原因发热(FUO)患者的病因分布以及临床特征。方法:筛查2018年1月1日至2019年12月31日期间在广州医科大学附属第一医院感染内科因FUO就诊的91例患者。分析91例FUO患者的病因分布、临床特征以及人口学资料、实验室检测和临床结局等。结果:91例符合FUO诊断的患者,依据病因分为5组:感染性疾病组59例(64.8%)、结缔组织疾病组17例(18.7%)、恶性肿瘤组6例(6.6%)、其他类疾病组3例(3.3%)和未明确病因组6例(6.6%)。所有研究对象入院时平均体温为38.2℃,感染性疾病组的主要临床表现为咳嗽,恶性肿瘤组的主要临床表现为黄疸和腰腹部疼痛,结缔组织疾病组的主要临床表现为关节疼痛或僵硬和皮疹。感染性疾病组的白细胞计数和C反应蛋白均高于其他组(P<0.05)。结论:感染性疾病是FUO的首要病因,其次为结缔组织疾病和恶性肿瘤。就病种而言,社区获得性肺炎是最常见的疾病。临床医师深入认识FUO,以及研究其病因和诊疗策略,对提高诊断准确率及效率具有十分重要的意义。
Objective:To analyze the etiological spectrum and clinical characteristics of 91 patients with fever of unknown origin(FUO).Methods:The clinical data of 91 patients treated for FUO in the Department of Infectious Diseases,First Affiliated Hospital of Guangzhou Medical University,between January 1 of 2018 and December 31 of 2019,were screened and analyzed for the etiological spectrum,clinical characteristics,patient demography,laboratory findings and clinical outcomes.Results:Ninety⁃one patients met the criteria of FUO diagnosis and were divided into 5 groups according to the etiology:59 cases(64.8%)in the infectious disease group,17(18.7%)in the connective tissue disease group,6(6.6%)in the malignant tumor group,and 3(3.3%)in the miscellaneous disease group and 6(6.6%)in the unclear etiology group.The mean body temperature of all subjects at admission was 38.2℃.The major clinical manifestations in the infectious disease group were cough;in the malignant tumor group,jaundice and waist/abdomen pain;in the connective tissue disease group,joint pain/stiffness and rash.The white blood cell count and C⁃reactive protein levels in the infectious disease group were higher than those in the other groups(P<0.05).Conclusion:Infectious diseases are the most frequent cause of FUO,followed by connective tissue diseases and malignant tumors.In terms of disease classification,community⁃acquired pneumonia is the most common cause.In⁃depth understanding of FUO and research on the etiology,diagnosis and treatment strategies of FUO among clinicians should be of great significance for improving the accuracy and efficiency of diagnosis.
作者
陈燕辉
张浩
曾文铤
Chen Yanhui;Zhang Hao;Zeng Wenting(Department of Infectious Medicine,First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120;Department of General Practice Medicine,Yuexiu District Zhuguang Street Community Health Service Center,Guangzhou 510120,China)
出处
《广州医科大学学报》
2021年第2期75-79,共5页
Academic Journal of Guangzhou Medical University
关键词
不明原因发热
病因
临床特征
Fever of unknown origin
Etiology
Clinical characteristics
