摘要
目的探讨小儿金翘颗粒联合干扰素α-2b对小儿疱疹性咽峡炎急性期的疗效观察及对患儿免疫功能和心肌酶的影响。方法选择杭州市第九人民医院2019年1月至2020年1月收治的疱疹性咽峡炎急性期患儿102例,依据随机数字表法分为观察组51例与对照组51例。对照组患儿给予干扰素α-2b治疗,观察组在对照组基础上口服小儿金翘颗粒。两组疗程均为5 d。比较两组主要症状消失时间,治疗前后体液免疫功能、细胞免疫功能和心肌酶变化及治疗疗效。结果观察组咽峡部疱疹消退时间[(3.05±0.74)d]、流涎消退时间[(2.31±0.68)d]和发热消退时间[(1.36±0.39)d]均短于对照组[(4.38±0.98)d、(3.83±1.07)d、(2.54±0.71)d](t=7.773、8.562、10.403,均P<0.05)。观察组治疗后血清IgA[(1.49±0.16)g/L]、IgG[(10.29±0.89)g/L]和IgM[(1.26±0.14)g/L]均高于对照组[(1.13±0.12)g/L、(9.35±0.72)g/L和(0.98±0.13)g/L](t=12.855、5.864、10.466,均P<0.05)。观察组治疗后CD3+[(74.29±2.15)%]、CD4^(+)[(40.85±1.65)%]和CD4^(+)/CD8+(1.87±0.23)均高于对照组[(67.96±2.43)%、(38.02±1.20)%和(1.49±0.14)](t=13.933、9.906、10.079,均P<0.05)。观察组治疗后血清肌酸激酶[(147.86±15.42)U/L]和乳酸脱氢酶[(128.64±14.25)U/L]均低于对照组[(176.95±13.15)U/L和(184.32±18.98)U/L](t=10.251、16.754,均P<0.05)。观察组总有效率[92.16%(47/51)]高于对照组[74.51%(38/51)](χ^(2)=5.718,P<0.05)。结论小儿金翘颗粒联合干扰素α-2b对急性期疱疹性咽峡炎患儿疗效明显,可改善患儿体液和细胞免疫功能,减轻心肌损害。
Objective To investigate the efficacy of Xiaoer Jinqiao granule combined with interferonα-2b on acute herpangina in children and its effect on immune function and myocardial enzyme.Methods A total of 102 children with acute herpangina who received treatment in Hangzhou Ninth People's Hospital from January 2019 to January 2020 were randomly assigned to receive treatment with either interferonα-2b(control group,n=51)or Xiaoer Jinqiao granule combined with interferonα-2b(observation group,n=51)for 5 d.The time to disappearance of main symptoms,changes in humoral immune function,changes in cellular immune function and myocardial enzyme level after treatment relative to before treatment as well as curative effect were compared between the control and observation groups.Results The time to disappearance of pharyngeal herpes[(3.05±0.74)d],salivation[(2.31±0.68)d],and fever[(1.36±0.39)d]in the observation group were significantly shorter than those in the control group[(4.38±0.98)d,(3.83±1.07)d,(2.54±0.71)d,t=7.773,8.562,10.403,all P<0.05].After treatment,serum IgA[(1.49±0.16)g/L],IgG[(10.29±0.89)g/L]and IgM[(1.26±0.14)g/L]levels in the observation group were significantly higher than those in the control group[(1.13±0.12)g/L,(9.35±0.72)g/L and(0.98±0.13)g/L,t=12.855,5.864 and 10.466,all P<0.05].After treatment,CD3+[(74.29±2.15)%],CD4^(+)[(40.85±1.65)%]and CD4^(+)/CD8+expression[(1.87±0.23)]in the observation group were significantly higher than those in the control group[(67.96±2.43)%,(38.02±1.20)%and(1.49±0.14),t=13.933,9.906 and 10.079,all P<0.05].After treatment,serum creatine kinase[(147.86±15.42)U/L]and lactate dehydrogenase[(128.64±14.25)U/L]in the observation group were significantly lower than those in the control group[(176.95±13.15)U/L and(184.32±18.98)U/L,t=10.251,16.754,both P<0.05].Total effective rate in the observation group was significantly higher than that in the control group[92.16%(47/51)vs.74.51%(38/51),χ^(2)=5.718,P<0.05].Conclusion Xiaoer Jinqiao granule combined with interferonα-2b has obvious curative effect on acute herpangina in children because it can improve the humoral and cellular immune function and reduce myocardial damage.
作者
高丽娜
夏菁
高佳
Gao Lina;Xia Jing;Gao Jia(Department of Pediatrics,Hangzhou Ninth People's Hospital,Hangzhou 311225,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2021年第3期344-348,共5页
Chinese Journal of Primary Medicine and Pharmacy
