摘要
目的探讨癫痫患者血浆谷氨酸(glutamic acid,Glu)、天冬氨酸(aspartic acid,Asp)、甘氨酸(glycine,Gly)及γ-氨基丁酸(γ-aminobutyric acid,GABA)水平与智力缺损程度的关系。方法选取2018年8月~2019年11月广西脑科医院神经内科就诊的癫痫患者82例为研究组,采用超高效液相-串联质谱法测定癫痫组及对照组血浆Glu,Asp,Gly和GABA浓度;采用韦氏智力量表(WAIS-RC)测量癫痫组及对照组智商(FIQ);同期健康体检者30例作为对照组。结果癫痫组血浆Glu,Asp水平(38.00±2.26,10.01±1.76 ng/ml)高于对照组(9.10±1.48,2.53±1.17 ng/ml),差异有统计学意义(t=64.916,21.502,均P<0.001);癫痫组血浆Gly,GABA水平(45±3.18,27.00±3.49 ng/ml)低于对照组(63.00±4.31,54.00±2.72 ng/ml),差异有统计学意义(t=23.891,38.206,均P<0.001)。癫痫组FIQ分值(64.43±15.72)低于对照组(101.50±18.40),差异有统计学意义(t=8.557,P<0.001)。癫痫组FIQ分值与血浆Glu,Asp水平呈正相关(r=0.879,0.724,均P<0.01),与Gly,GABA水平呈负相关(r=-0.775,-0.459,均P<0.01)。结论癫痫患者血浆Glu,Asp,Gly和GABA水平与其智力缺损的严重程度相关,可能是癫痫患者智力缺损程度的潜在标志物。
Objective To investigate the relationship between the levels of Glutamic acid(Glu),Aspartic acid(Asp),Glycine(Gly)andγ-aminobutyric acid(GABA)and the degree of mental retardation in epileptic patients.Methods From August 2018 to November 2019,82 patients with epilepsy were selected as the study group.The plasma concentrations of Glu,Asp,Gly and GABA in the epilepsy group and the control group were determined by UPLC-MS.Wechsler Intelligence Scale(WAIS-RC)was used to measure IQ(FIQ)of epilepsy group and control group.In the same period,30 healthy subjects were used as the control group.Results The levels of plasma Glu and Asp in epilepsy group(38.00±2.26,10.01±1.76ng/ml)were higher than those in control group(9.10±1.48,2.53±1.17ng/ml),the difference were statistical significance(t=64.916,21.502,all P<0.001).The levels of plasma GLY and GABA in the epilepsy group(45±3.18,27.00±3.49 ng/ml)were lower than those in the control group(63.00±4.31,54.00±2.72 ng/ml),and the difference was statistically significant(t=23.891,38.206,all P<0.001).The FIQ score of epilepsy group(64.43±15.72)was lower than that of control group(101.50±18.40),and the difference was statistically significant(t=8.557,P<0.001).In epilepsy group,FIQ score was positively correlated with plasma Glu and Asp levels(r=0.879,0.724,all P<0.01),and negatively correlated with Gly and GABA levels(r=-0.775,-0.459,all P<0.01).Conclusion The levels of plasma Glu,Asp,Gly and GABA are correlated with the severity of mental retardation in patients with epilepsy,which may be a potential marker of mental retardation in patients with epilepsy.
作者
漆明
王宇
李春
黄翔
QI Ming;WANG Yu;LI Chun;HUANG Xiang(Department of Clinical Laboratory,Guangxi Brain Hospital,Guangxi Liuzhou 545005,China;Department of Neurology,Guangxi Brain Hospital,Guangxi Liuzhou 545005,China)
出处
《现代检验医学杂志》
CAS
2021年第2期101-104,139,共5页
Journal of Modern Laboratory Medicine
基金
广西壮族自治区卫健委科研项目(Z20180062)。
关键词
癫痫
谷氨酸
天冬氨酸
甘氨酸
Γ-氨基丁酸
智商
epilepsy
glutamic acid
aspartic acid
glycine
γ-aminobutyric acid
intelligence quotient
