摘要
视觉诱发电位(VEP)是视觉受刺激后,在大脑视觉皮质所产生的电信号,可通过在头皮上的电极进行采集并进行信号分析。VEP为视力检查,尤其是不能说话的婴儿、智力低下或装病的成年人以及患有各种视觉障碍的患者的视力检查,提供了客观且定量的方法。针对VEP视力检查技术,从脑电设备平台、视觉刺激范式、实验参数设置、视力阈值判定算法和临床应用等方面对相关文献进行了综述比较,并且发现:在脑电设备平台方面,目前研究几乎全部采用只能在实验室环境下使用的专用脑机接口系统,缺失可面向广泛用户使用的临床设备;在刺激范式方面,相对于传统的光栅和棋盘格图案,振荡收缩扩张的同心环刺激范式显示了优异的抗疲劳性和低对比敏感性;在实验参数设置方面,7.5 Hz和1 Hz的稳态和瞬态VEP时间频率、中度数值的亮度和对比度、3~30周/(°)的空间频率范围更多地被采用;在视力阈值判定算法方面,最常用的是线性外推法和最小尺寸法;在临床应用方面,VEP技术主要应用于儿童视力发育评估和多种视觉疾病的视力客观检查。文献综述表明:VEP视力检测技术急需制定一个统一的规范标准,使其能有更广泛、更快速的应用,使VEP乃至电生理学在视觉功能检测与诊断方面的研究更加深入。
Visual evoked potential(VEP)is electrical signal induced by visual stimulation and generated in the visual cortex of the brain,which can be collected and analyzed by electrodes on the scalp.VEP provides an objective and quantitative method for visual acuity estimation,especially in non-verbal infants,adults with low intellectual abilities or malingering,and patients with various visual impairments.Aiming at the VEP visual acuity examination technology,this paper reviewed and compared the relevant literature from the aspects of electroencephalogram(EEG)equipment platform,visual stimulation paradigm,experimental parameter setting,visual acuity threshold determination algorithm and clinical application.It is found that in the EEG equipment platform,the current researches almost depend on the dedicated brain-computer interface(BCI)systems,lacking commercial equipment.In terms of stimulation paradigm,compared with the traditional grating and checkerboard patterns,the concentric-ring stimulation paradigm of oscillating contraction and expansion shows its excellent anti-fatigue performance and low contrast sensitivity.According to the experimental parameter setting,the temporal frequencies of 7.5 Hz and 1 Hz of steady-state and transient VEP,medium-value of luminance and contrast,and the spatial frequency range of 3-30 cycles/(°)are mostly adopted.In threshold determination algorithm,the most commonly used strategies are linear extrapolation method and minimum size method.In clinical application,VEP technology is mainly used in the assessment of children’s visual acuity development and the objective visual acuity evaluation in various visual diseases.This review shows that VEP visual acuity assessment technology urgently needs a unified standard,so that it can be expected to have wider and faster applications and excites the research on VEP and even electrophysiology in vision function detection and diagnosis at higher level.
作者
徐光华
郑小伟
田沛源
杜成航
张四聪
XU Guanghua;ZHENG Xiaowei;TIAN Peiyuan;DU Chenghang;ZHANG Sicong(School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, China;State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710054, China)
出处
《西安交通大学学报》
EI
CAS
CSCD
北大核心
2021年第3期1-10,共10页
Journal of Xi'an Jiaotong University
基金
中央高校建设世界一流大学(学科)和特色发展引导专项资金资助项目(PY3A071)。
关键词
脑机接口
视觉诱发电位
视力检查
刺激范式
阈值判定
brain-computer interface
visual evoked potential
visual acuity examination
stimulation paradigm
threshold determination
