摘要
目的探讨生长抑素联合精准营养疗法对胃癌根治术患者术后营养指标水平和肠道菌群的影响。方法选取我院2017年10月至2019年1月收治并拟行胃癌根治术治疗的92例胃癌患者为研究对象,随机分为对照组(46例)和观察组(46例)。两组患者术后均给予常规处理。对照组患者同时给予生长抑素+常规肠外营养支持,观察组患者同时给予生长抑素+精准营养支持。于营养干预前后统计两组患者营养相关指标[体质量、血清白蛋白(ALB)、前白蛋白(PA)、淋巴细胞计数(LC)、肌酐(Ct)以及尿素氮(UN)]水平;对肠道菌群进行alpha分析,并计算肠杆菌、肠球菌、乳杆菌和双歧杆菌数量。结果营养干预前,两组患者营养相关指标水平以及肠道菌群相关指标水平之间差异无统计学意义(均P>0.05)。营养干预后,(1)观察组患者平均体质量以及血清ALB、PA、LC水平分别为(56.98±5.34)kg、(29.98±6.03)mg/L、(137.14±35.17)g/L、(1.15±0.26)×109,对照组分别为(53.29±5.18)kg、(26.12±5.29)mg/L、(104.53±27.66)g/L、(0.82±0.18)×109,两组之间差异有统计学意义(均P<0.05);(2)观察组患者肠道菌群Chao指数和Ace指数水平分别为(397.84±75.23)、(408.26±78.34),对照组分别为(362.13±66.23)、(371.19±70.09),两组之间差异有统计学意义(均P<0.05);(3)观察组患者肠道肠杆菌、肠球菌数量明显低于对照组,而乳杆菌、双歧杆菌数量明显高于对照组(均P<0.05)。结论胃癌根治术患者术后联合生长抑素和精准营养疗法能够显著改善患者的营养状况,保持肠道菌群丰度,平衡肠道菌群分布,值得临床研究和应用。
Objective To explore the effects of precision nutrition therapy combined with Somatostatin on nutritional status and intestinal flora after radical gastrectomy for gastric cancer.Methods A total of 92 patients with gastric cancer who underwent radical gastrectomy in our hospital from October 2017 to January 2019 were enrolled and randomly divided into control group(46 cases)or observation group(46 cases).Routine treatment was given after operation.The patients in control group received somatostatin plus routine parenteral nutrition support,while those in observation group received somatostatin plus precision nutrition therapy.The nutrition-related indicators(weight,ABL,PA,LC,Ct,UN)in the two groups before and after nutrition intervention,result of alpha analysis of intestinal flora,and the numbers of intestinal Enterobacter,Enterococcus,Lactobacillus and Bifidobacterium were analyzed.Results Before nutritional intervention,there were no significant differences between the two groups in nutrition-related indicators and intestinal flora-related indicators(all P>0.05).After nutritional intervention,(1)the average body weight and serum levels of ALB,PA,LC in the observation group were(56.98±5.34)kg,(29.98±6.03)mg/L,(137.14±35.17)g/L,(1.15±0.26)×10~9,the control group were(53.29±5.18)kg,(26.12±5.29)mg/L,(104.53±27.66)g/L,(0.82±0.18)×10~9,the difference between the two groups had statistical significance(all P<0.05);(2)The intestinal floral Chao and Ace indicators in the observation group(397.84±75.23,408.26±78.34)were significantly higher than those in the control group(362.13±66.23,371.19±70.09);(3)The numbers of Enterobacter and Enterococcus in the observation group were significantly lower,while the numbers of Lactobacillus and Bifidobacterium were significantly higher than those in the control group respectively(all P<0.05).Conclusion The combination of Somatostatin and precision nutrition therapy after radical gastrectomy for gastric cancer can significantly improve the nutritional status of patients,maintain intestinal floral abundance,and regulate the balance of intestinal flora.
作者
王松
余阳
胡赤丁
肖丹
WANG Song;YU Yang;HU Chiding;XIAO Dan(Internal Medicine of the Sixth Hospital of Wuhan Affiliated Hospital of Jianghan University,Wuhan,Hubei 430015,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2020年第11期1314-1318,共5页
Chinese Journal of Microecology
关键词
胃癌根治术
生长抑素
精准营养疗法
营养状况
肠道菌群
Radical gastrectomy for gastric cancer
Somatostatin
Precision nutrition therapy
Nutritional status
Intestinal flora
