摘要
目的:探讨胃癌病人血清中β2-微球蛋白(β2-microglobulin,β2-MG)含量变化及临床应用价值。方法用免疫放射分析法(IRA)检测62例胃癌病人、30例慢性胃炎伴幽门螺杆菌(helicobacterpylori,HP)感染病人以及3例正常健康人血清β2-MG含量。动态检测胃癌手术前后β2-MG含量变化。结果:胃癌病人血清中β2-MG含量明显高于健康对照组(P<0.05)和慢性胃炎伴HP组(P<0.05);胃癌患者术前血清β2-MG含量增高者,术后含量明显降低(P<0.05);有转移复发时,其含量又升高。结论:检测血清β2-MG含量变化在胃癌早期诊断以及疗效和预后判断等方面具有重要临床意义。
Objective To explore the change of the serum level of β2-microglobulin （β2-MG） and its clinical significance in the patients with gastric cancer. Methods 62 patients with gastric cancer, 30 patients with chronic gastritis accompanied by HP infection, and 30 healthy individuals were included in the study, their serum levels of β2-MG were measured by IRA. The changes of β2-MG serum levels in the patients with gastric cancer were measured pre-and postoperatively. Results The level of serum β2-MG in the patients with gastric cancer was markedly higher than those in the patients with chronic gastritis accompanied by HP infection （ P〈0.05） and in the healthy controls （ P〈0.05）. The high level of serum β2-MG in patients with gastric cancer was dramatically decreased after surgery （ P〈0.05）, whereas the decreased level of serum β2-MG would elevate again when metastasis or recurrence occurred. Conclusion Detection of the changes of serum β2-MG level may have a clinical significance in the early diagnosis, prediction of prognosis and therapeutic efficacy for the patients with gastric cancer.
出处
《实用医学杂志》
CAS
2006年第11期1255-1256,共2页
The Journal of Practical Medicine
关键词
胃肿瘤
β1-微球蛋白
辅助诊断
复发
Stomach neoplasms β2-microglobulin Asisting diagnosis Relapse
