摘要
随着环境污染、资源枯竭和医疗健康等问题的加剧,研发同时满足特定使用性能、安全性及可再生性的新型材料成为当前的发展趋势.而丝素蛋白材料正是以天然蚕丝为基本原材料,经一定的加工和功能化而形成的具有特殊结构、独特性能和广泛应用的生物质材料,近年来在生物医药、生物电子、智能传感等领域展现出巨大的应用潜力.本专论总结了丝素蛋白纤维及功能化材料的最新成果,结合本课题组相关工作,重点阐述了再生丝素蛋白纤维的仿生制备、生物医用支架的构筑与功能化、智能电子材料的设计以及天然多功能蚕丝及其构筑基元制备的研究进展,以期为高性能丝素蛋白材料的设计与构筑提供指导和借鉴.
With the advent of environmental pollution,resource depletion,and medical and health problems,the fabrication of new materials that meet specific performance standards,green safety and reproducibility has become the focus of current research.Silk fibroin,originating from natural silkworm cocoons,is among the most important renewable material due to its excellent biocompatibility,biodegradability,optical properties,thermal stability,and mechanical strength.Furthermore,silk fibroin can be processed,functionalized and produced in a variety of forms,such as porous scaffolds,hydrogels,membranes,and fibers,which endows silk fibroin-based materials(SFBM)with special structure,unique performance and increases their potential fields of application into biomedicine,bioelectronics,and intelligent sensing.However,there are still many challenges to fabricate SFBM with excellent performance on a large scale.Firstly,conventional methods of processing destroy the multilevel structure of silk firoin,which restricts its biomimetic design and results in degradation of its performance.Secondly,it is difficult to precisely regulate the structure of silk fibroin and ensure consistent performance across different batches.Thirdly,the performance of SFBM is comparatively inferior to that of synthetic polymers and can easily deteriorate when exposed to light,heat,or radiation.Therefore,the development of simple,efficient,biomimetic processing strategies to regulate the structure,improve the performance,and clarify the structure-function relationships of SFBM is of considerable significance.The present review summaries the latest achievements and developments of silk fibroin-based fibers and functional materials,focusing on the progress of research into biomimetic preparation of regenerated silk fibroin,the construction and functionalization of biomedical scaffolds,the design of intelligent electronic materials,and the fabrication of natural multifunctional silk and its building blocks.The aim of this review is to provide guidance and a reference for the design and construction of high-performance SFBM.
作者
范苏娜
陈杰
顾张弘
姚响
张耀鹏
Su-na Fan;Jie Chen;Zhang-hong Gu;Xiang Yao;Yao-peng Zhang(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620)
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2021年第1期29-46,I0003,I0001,共20页
Acta Polymerica Sinica
基金
国家重点研发计划(项目号2018YFC1105800)
国家自然科学基金(基金号21674018,51903045)
国家重点研发计划(项目号2016YFA0201700)
上海市优秀学术带头人计划(项目号20XD1400100)
上海市自然科学基金(基金号20ZR1402400)资助.
关键词
丝素蛋白
多级结构
功能材料
仿生构筑
Silk fibroin
Hierarchical structure
Functional materials
Biomimetic fabrication
