摘要
目的分析儿童神经母细胞瘤(NB)的临床特点及影响生存率的因素,为进一步优化儿童NB诊治方案提供依据。方法以2016年4月至2020年2月收治的44例NB患儿为研究对象,回顾性分析患儿的临床资料及随访资料。结果44例NB患儿初次就诊常见临床症状依次为发热(10/44,23%)、发现肿块(9/44,20%)、腹痛(8/44,18%)、咳嗽(7/44,16%)、面色苍白(3/44,7%)、跛行(2/44,5%)及活动异常(2/44,5%)。根据INSS分期,Ⅰ期2例(4%)、Ⅱ期5例(11%)、Ⅲ期5例(11%)、Ⅳ期32例(73%)。44例患儿平均随访时间为(15.3±1.5)个月,复发率为20%,总生存率为82%,其中无事件生存29例(66%),带瘤生存7例(16%)。病理类型为NB、血清神经元特异性烯醇化酶增高可降低NB患儿的总生存率(P<0.05)。结论NB患儿初诊临床症状无明显特异性,多以发热、腹痛、发现肿块最常见;初诊晚期患儿占比高;病理分型为NB、血清神经元特异性烯醇化酶增高可能与NB患儿总生存率降低有关。[中国当代儿科杂志,2020,22(11):1193-1197]
Objective To study the clinical features of neuroblastoma(NB)and the factors influencing survival rate.Methods A total of 44 children with NB who were admitted from April 2016 to February 2020 were enrolled as research subjects.A retrospective analysis was performed on their medical data and follow-up data.Results The common clinical symptoms of these 44 children were fever(10/44,23%),mass(9/44,20%),abdominal pain(8/44,18%),cough(7/44,16%),pale complexion(3/44,7%),claudication(2/44,5%),and abnormal activity(2/44,5%).According to the INSS stage,2 children(4%)had stage I NB,5 children(11%)had stage II NB,5 children(11%)had stage III NB,and 32 children(73%)had stage IV NB.The mean follow-up time was(15.3±1.5)months,with a recurrence rate of 20%and an overall survival rate of 82%.Among the 44 children,29(66%)achieved event-free survival and 7(16%)had survival with tumor.The univariate analysis showed that a pathological type of NB and an increase in serum neuron-specific enolase(NSE)decreased the overall survival rate of children with NB(P<0.05).Conclusions The clinical symptoms of children with NB are not specific at the first visit.Fever,abdominal pain,and mass are common symptoms,and there is a high proportion of children in the advanced stage.The pathological type of NB and an increase in serum NSE may be associated with a reduction in the overall survival rate of children with NB.[Chin J Contemp Pediatr,2020,22(11):1193-1197]
作者
朱呈光
贺湘玲
汤止戈
陈可可
邹润英
田鑫
游亚兰
ZHU Cheng-Guang;HE Xiang-Ling;TANG Zhi-Ge;CHEN Ke-Ke;ZOU Run-Ying;TIAN Xin;YOU Ya-Lan(Department of Pediatric Hematology and Oncology,Hunan Provincial People's Hospital,Changsha 410005,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2020年第11期1193-1197,共5页
Chinese Journal of Contemporary Pediatrics
基金
儿童实体肿瘤精准诊疗的基础与临床研究-湖南省科技厅重点研发项目(2018SK21216)。
