摘要
骨转移是肺癌的常见并发症之一,随着患者生存率的提高骨转移的发生风险也随之增加。肺癌骨转移动物模型是研究肺癌骨转移的重要工具,对阐释肺癌骨转移的病理生理学机制,研发和评价肺癌治疗药物都具有重要意义。本文综述了国内外报道的肺癌骨转移动物模型的研究现状,对肺癌细胞株、实验动物的品系、模型构建方法以及评价方法进行详细的论述,对于肺癌的研究具有重要的参考价值。
Bone metastasis is a common complication of lung cancer,and patient survival rate increases its risk.Animal models of bone metastasis are useful to investigate lung cancer bone metastasis.An explanation of the pathophysiology of lung cancer bone metastasis is important for medical research in lung cancer.In this paper we review domestic and foreign reports on the research status of animal models of lung cancer bone metastasis and discuss lung cancer cell lines,experimental animal strains,model building method,and evaluation method in detail.It is hoped that this paper will be an important reference for the study of lung cancer.
作者
张娜
刘学芳
冯素香
董浩然
ZHANG Na;LIU Xuefang;FENG Suxiang;DONG Haoran(College of Basic Medicine,Henan University of Chinese Medicine,Zhengzhou 450046;China.2.Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第10期128-131,137,共5页
Chinese Journal of Comparative Medicine
基金
河南省高等学校重点科研项目(20A360007)。
关键词
肺癌
骨转移
动物模型
lung cancer
bone metastasis
animal model
