摘要
目的探讨非小细胞肺癌(NSCLC)患者表皮生长因子受体(EGFR)突变情况与临床病理特征之间的相关性。方法回顾性分析2016年5月—2019年6月克拉玛依市中心医院病理科检测的215例NSCLC石蜡样本,所有样本均采用实时荧光定量PCR技术检测EGFR突变。结果(1)在215例NSCLC标本中EGFR基因突变率25.12%(54/215),女性的EGFR突变率明显高于男性(35.05%vs19.23%,P=0.01),EGFR突变型肿物直径均值明显高于EGFR野生型(1.39±0.89 cm vs 2.15±1.84cm(P<0.01));(2)NSCLC伴癌周肺组织炎症(包括机化性肺炎,间质性肺炎等)的EGFR突变率显著低于癌周肺组织正常患者(35.13%vs71.93%,P=0.00);(3)EGFR突变率与NSCLC伴发其他恶性肿瘤病史(0.00%vs 33.33%,P=0.00)、伴发过敏史(14.28%vs 26.29%,P<0.05)等临床因素呈显著负相关;(4)在发病年龄、NSCLC伴发呼吸系统及心血管系统慢性病史、临床经过有无症状等临床因素对比中,EGFR突变检出率无显著差异。结论NSCLC患者的EGFR突变率与临床病理特征的关系具有多样性,EGFR突变率与性别、肿物直径、病理组织类型、分化程度呈显著正相关,与是否罹患其他恶性肿瘤病史、过敏史、癌周炎症状态呈现显著负相关。
Objective To study the correlation between the mutations of epidermal growth factor receptor(EGFR)gene and the clinicopathological characteristics in patients with non-small cell lung cancer(NSCLC).Methods A retrospective analysis of 215 NSCLC paraffin samples detected in the pathology department of Karamay Central Hospital from May 2016 to June 2019,EGFR mutations were detected by real-time fluorescence quantitative PCR technology in all samples.Results(1)In 215 NSCLC specimens,the mutation rate of EGFR gene was 25.12%(54/215),and the EGFR mutation rate in females was significantly higher than that in males(35.05%vs19.23%,P=0.01).The mean diameter of EGFR mutant tumors was significantly higher than that of EGFR wild type tumors.(2)The EGFR mutation rate of NSCLC with peri-cancerous tissue inflammation(including organizing pneumonia,interstitial pneumonia,etc.)is significantly lower than that of patients with normal lung tissue around cancer(35.13%vs 71.93%,P=0.00).(3)The EGFR mutation rate is significantly negatively correlated with clinical factors such as the history of NSCLC with other malignant tumors(0.00%vs 33.33%,P=0.00)and allergies(14.28%vs 26.29%,P<0.05).(4)There was no significant difference in the detection rate of EGFR mutations in the comparison of clinical factors such as age of onset,chronic history of NSCLC with respiratory and cardiovascular systems,and clinical history with or without symptoms.Conclusion The relationship between EGFR mutation rate and clinicopathological characteristics of NSCLC patients is diverse.EGFR mutation rate is significantly positively correlated with gender,tumor diameter,pathological tissue type and differentiation degree,and is significantly negatively correlated with the history of other malignant tumors,allergy history and peri-cancerous inflammatory state.
作者
姜敏
高静
王雨婷
梁飞
朱敏
马玉花
JIANG Min;GAO Jing;WANG Yuting;LIANG Fei;ZHU Min;MA Yuhua(Karamay Central Hospital,Karamay 834000,Xinjiang,China;East Hospital,Tongji University School of Medicine,Shanghai 200120,China)
出处
《新疆医学》
2021年第7期757-760,共4页
Xinjiang Medical Journal
基金
新疆维吾尔自治区自然科学基金面上项目,(项目编号:2021D01A21)
克拉玛依市中心医院院级项目,(项目编号:YK2019-1 YK2019-7)
关键词
癌
非小细胞
表皮生长因子受体
突变
Carcinoma
non-small-cell
epidermal growth factor receptor
Mutation
