摘要
目的:观察秋水仙碱联合非布司他治疗痛风性关节炎的疗效。方法:将80例痛风性关节炎患者随机分为治疗组和对照组,每组40例。对照组给予非布司他单药口服治疗,治疗组在对照组治疗基础上加服秋水仙碱。2组均以12周为1个疗程。观察2组患者治疗前后痛风症状积分、血尿酸水平,以及药物不良反应。结果:治疗后,2组痛风症状积分、血尿酸水平较治疗前均有改善(P<0.05),且治疗组优于对照组(P<0.05);治疗组药物不良反应率为7.5%,对照组为5%,2组比较,差异无统计学意义(P>0.05)。结论:秋水仙碱联合非布司他治疗痛风性关节炎疗效优于单一使用非布司他。
Objective:To observe the efficacy of colchicine combined with febuxostat in the treatment of gouty arthritis.Methods:Eighty patients with gouty arthritis were randomly divided into a treatment group and a control group,40 cases in each group.The control group was treated with febuxostat,while the treatment group was given colchicine based on the treatment for the control group.The course of treatment was 12 weeks for both groups.Gout symptoms,serum uric acid level and adverse reactions were observed before and after treatment.Results:After treatment,gout symptoms and serum uric acid levels in both groups were improved compared with those before treatment(P<0.05),and the treatment group was better than the control group(P<0.05);the adverse drug reaction rate of the treatment group was 7.5%,and that of the control group was 5%,with no significant difference between the two groups(P>0.05).Conclusion:The efficacy of colchicine combined with febuxostat in the treatment of gouty arthritis is better than that of single use of febuxostat.
出处
《风湿病与关节炎》
2020年第10期18-19,43,共3页
Rheumatism and Arthritis
