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细胞色素氧化酶CYP2C9的研究进展 被引量：20

Recent Advance of Cytochrome P450 2C9
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摘要 CYP2C9是人类肝脏中含量丰富的一种CYP450酶，它能代谢和/或活化许多种药物、前致癌物、前毒物和致突变剂。CYP2C9基因具有遗传多态性，在人类存在几种等位基因的突变体。本文从基因结构、底物和探针药、影响其活性的因素、遗传多态性的分子机制等方面综述CYP2C9的研究进展。 As an abundant CYP450 form in human liver, CYP2C9 can metabolize and/or activate a large variety of drugs, pre-carcinogens, pre-toxins and mutagens. CYP2C9 gene has several mutant alleles leading to genetic polymorphisms in humans. In the present article, the CYP2C9 gene structure, the underlying molecular mechanisms for its genetic polymorphisms, the substrates and probe drugs toward CYP2C9, and factors affecting its enzyme activity are reviewed.
作者 卢爱华 舒焱 周宏灏
机构地区 深圳康力医药公司 School of Pharmac 湖南医科大学基础与临床药理研究所
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2000年第5期381-385,共5页 The Chinese Journal of Clinical Pharmacology
基金 国家自然科学基金重点项目!(No. F39330230) 美国中华医学基金项目!(No.92-568 No.99-697)
关键词 细胞色素氧化酶 研究进展 CYP2C9 药物代谢 遗传多态性 基因突变 遗传药理学 CYP2C9 drug metabolism genetic polymorphism gene mutation pharmacogenetics
分类号 R969.1 [医药卫生—药理学]
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  • 11.Mechan RR, Gosden JR, Rout D, et al. Human cytochrome P450PB-1:A multigene family involved in mephenytoin and steroid oxidations that maps to human chromosome 10. Am J Hum Genet, 1988; 48: 26～37.
  • 22.Kimura S, Pastewka J, Gelboin HV, et al. cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. Nucleic Acids Res, 1987; 15: 10053～10054.
  • 33.Vermeij P, Ferrari MD, Buruma OJ, et al. Inheritance of poor phenytoin parahydroxylation capacity in an Dutch family. Clin Pharmacol Ther, 1988; 44: 588～593.
  • 44.Sullivan-Klose TH, Ghanayem BI, Bell DA, et al. The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics, 1996; 6: 341～349.
  • 55.Brian WR, Srivastava PK, Umbenhauer DR, et al. Expression of a human liver cytochrome P450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Biochemitry, 1989; 28: 4993～4999.
  • 66.Jones BC, Hawksworth G, Horne VA, et al. Putative active site template model for cytochrome P450 (tolbutamide hydroxylase). Drug Meta Dispo,1995; 24: 260～266.
  • 77.Miners JO, Rees DLP, Valenre L, et al. Human hepatic cytochrome P450 catalyzes the rate limiting pathway of torasemide metabolism. J Pharmacol Exp Ther, 1995; 272: 1076～1081.
  • 88.Rettie AE, Wienkers LC, Gonzalez FJ, et al. Impaired (S)-warfarin metabolism catalyzed by the R144C allelic variant of CYP2C9. Pharmacogenetics, 1994; 4: 39～42.
  • 99.Vasco MR, Dell RD, Daly DD, et al. Inheritance of phenytoin hypometabolism: a kinetic study of one family. Clin Pharmacol Ther,1980; 27: 96～103.
  • 1010.Inaba T. Phenytoin: pharmacogenetic polymorphism of 4?hydroxylation.Pharmacol Ther, 1990; 46: 341～347.

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中国临床药理学杂志
2000年 第5期

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