摘要
支气管哮喘是儿童最常见的慢性呼吸道疾病,以气道高反应性及可逆性气流受限为特征。细颗粒物(particular matter 2.5,PM2.5)通过氧化应激、免疫炎症损伤、气道高反应性等机制,对哮喘产生显著影响。该文就PM2.5的来源、组成、理化性质,PM2.5致哮喘的机制,以及其对支气管哮喘急性发作、急门诊就诊率、住院率、肺功能及呼出气一氧化氮的影响等方面进行综述。
Bronchial asthma is one of the most common childhood chronic respiratory diseases characterized by airway hyperresponsiveness and reversible airflow limitation.Air pollution,especially PM2.5(fine particle size≤2.5 microns)has a significant effect on asthma,through oxidative stress,immune inflammatory injury,airway hyperresponsiveness and other mechanisms.This paper describes the source,composition,physical and chemical properties of PM2.5,the mechanism of PM2.5 induced asthma,and its effects on acute bronchial asthma attack,acute outpatient consultation rate,hospitalization rate,lung function and exhaled nitric oxide(FeNO).
作者
王斌艳(综述)
韩志英(审校)
Wang Binyan;Han Zhiying(Departmentof Pediatrics,Shanxi Medical University,Taiyuan 030001,China;Respiratory Department of Shanxi Children′s Hospital,Taiyuan 030013,China)
出处
《国际儿科学杂志》
2020年第8期539-543,共5页
International Journal of Pediatrics
基金
大气重污染成因与治理攻关项目(DQGG0402)。
