摘要
目的:探讨Peroxiredoxin-6(Prdx6)在老年急性髓系白血病(AML)患者骨髓细胞中的表达及其临床意义。方法:采用荧光定量聚合酶链式反应(PCR)技术检测33例AML患者、8例CML患者、11例其他血液病患者骨髓细胞中Prdx6基因的表达,进一步分析Prdx6异常表达与AML患者年龄及血常规参数的相关性。结果:年龄较大(≥60岁)的AML患者的Prdx6表达水平明显低于年龄较小(<60岁)的患者(P<0.05);低WBC计数组(≤1×10^9/L)的Prdx6表达水平明显低于中等WBC计数组(1-10)×10^9/L及高WBC计数组(>10×10^9/L)(P<0.05);年龄较大的患者中WBC计数≤1×10^9/L的比例达到38.5%,明显高于年龄较小的患者(5%,P<0.05);年龄较大的患者总生存(OS)率明显低于年龄较小的患者(P<0.05)。结论:老年AML患者中Prdx6低表达,且与外周血WBC基础值偏低相关,这可能是老年AML患者预后不良因素之一。
Objective:To study the expression of Peroxiredoxin-6(Prdx6)gene in elderly patients with acute myeloid leukemia(AML)and its clinical significance.Methods:The expression level of Prdx6 in bone marrow cells of 33 cases of AML,8 cases of CML and 11 cases of other blood diseases was detected by PCR.The correlation of the abnormal expression of Prdx6 with patient age and blood routine parameters was further analyzed.Results:the expression level of Prdx6 in elderly patients with AML(≥60 years)was significantly lower than that in younger patients(<60 years)(P<0.05);the expression level of Prdx6 in low WBC(≤1×10^9/L)group was lower than that in medium WBC(1-10×10^9/L)group or high WBC(>10×10^9/L)group(P<0.05);the proportion of WBC count(≤1×10^9/L)in elderly patients with AML reached 38.5%,which was significantly higher than that in younger patients(5%)(P<0.05);the overall survival(OS)rate of elderly patients was lower than that of younger patients(P<0.05).Conclusion:The expression of Prdx6 in elderly patients with AML is low,moreover,it relates with low value of WBC in peripheral blood,suggesting that it may be one of poor prognostic factors for the elderly patients with AML.
作者
杨海玉
柯波
文丽丹
陈小霞
刘勇
YANG Hai-Yu;KE Bo;WEN Li-Dan;CHEN Xiao-Xia;LIU Yong(Institute of Clinical Medicial Sciences,Jiangxi Provincial People′s Hospital,Nanchang 330006,Jiangxi Province,China;Department of Hematology,Jiangxi Provincial People′s Hospital,Nanchang 330006,Jiangxi Province,China;Department of Pathology,Jiangxi Provincial People′s Hospital,Nanchang 330006,Jiangxi Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2020年第4期1157-1161,共5页
Journal of Experimental Hematology
基金
国家自然科学基金项目(81760038)
江西省卫计委科技计划(20161014)。
