摘要
目的:探讨血清细胞因子受体样因子1(CRLF1)、过氧化物还原蛋白6(PRDX6)对早期胃癌内镜黏膜下剥离术(ESD)后复发的预测价值。方法:选取早期胃癌患者82例(均行ESD治疗)为研究组,选取同期病理检查确诊的良性病变患者82例为对照组。采用实时荧光定量PCR检测CRLF1、PRDX6 mRNA水平,分析两者相关性、ESD术后复发影响因素及对ESD术后复发的预测价值。结果:与对照组比较,研究组血清CRLF1 mRNA降低,PRDX6 mRNA水平升高(均P<0.05)。血清CRLF1 mRNA与PRDX6 mRNA呈负相关(r=-0.596,P<0.05)。经1年随访,82例患者中,16例复发。复发组黏膜下浸润占比高于未复发组(P<0.05)。复发组血清CRLF1 mRNA水平显著低于未复发组,血清PRDX6 mRNA水平显著高于未复发组(均P<0.05)。浸润深度、PRDX6 mRNA为危险因素,CRLF1 mRNA为保护因素(均P<0.05)。血清CRLF1 mRNA、PRDX6 mRNA对早期胃癌ESD术后复发均有良好的预测价值,两项联合预测优于单项预测(均P<0.05)。结论:早期胃癌患者血清CRLF1水平明显降低,PRDX6水平明显升高,两项联合检测对胃癌ESD术后复发有良好的预测价值。
Objective:To investigate the predictive value of serum cytokine receptor-like factor 1(CRLF1)and peroxiredoxin 6(PRDX6)for recurrence after endoscopic submucosal dissection(ESD)in early gastric cancer.Methods:Eighty-two cases of early gastric cancer patients(all of whom were treated with ESD)were selected as study group,and another 82 cases of benign lesions diagnosed by pathological examination during the same period were selected as control group.Real-time fluorescence quantitative PCR was used to detect the levels of CRLF1 and PRDX6 mRNA,and to analyze the correlation between them,the factors influencing the recurrence after ESD and the predictive value for the recurrence after ESD.Results:Compared with the control group,the serum CRLF1 mRNA level was decreased and PRDX6 mRNA level was increased in the study group(both P<0.05).Serum CRLF1 was negatively correlated with PRDX6 mRNA(r=-0.596,P<0.05).After 1 year of follow-up,16 of the 82 patients had recurrence.The proportion of submucosal infiltration in the recurrence group was higher than that in the non-recurrence group(P<0.05).The serum CRLF1 mRNA level in the recurrence group was obviously lower than that in the non-recurrence group,and the serum PRDX6 mRNA level was prominently higher than that in the non-recurrence group(all P<0.05).Infiltration depth and PRDX6 mRNA were risk factors,and CRLF1 mRNA was a protective factor(all P<0.05).Serum CRLF1 mRNA and PRDX6 mRNA had good predictive value for recurrence after ESD for early gastric cancer,and the combination of the two was better than single prediction(both P<0.05).Conclusion:Serum CRLF1 level is significantly decreased and PRDX6 level is significantly increased in patients with early gastric cancer.The combined detection of the two indexes has a good predictive value for the recurrence of gastric cancer after ESD.
作者
刘梦荻
董锦
姜中华
LIU Mengdi;DONG Jin;JIANG Zhonghua(Department of Gastroenterology,Yancheng No.1 People’s Hospital,Yancheng 224000,China)
出处
《陕西医学杂志》
2025年第9期1233-1236,1290,共5页
Shaanxi Medical Journal
基金
江苏省基础研究计划(自然科学基金)专项资金资助项目(BK20210265)。
