摘要
肝细胞癌是一种发病率高、早期发病不易察觉、预后较差的恶性肿瘤。姜黄素是从姜科植物中提取的一种天然的酚类抗氧化剂,具有多种药理作用,可抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞迁移与侵袭、调控肿瘤表观遗传、抑制肿瘤新血管生成、诱导肿瘤细胞自噬、延缓或逆转肿瘤耐药。对姜黄素抗肝癌的作用机制进行总结,以期为肝癌的临床治疗提供思路和方法。
Hepatocellular carcinoma is a highly prevalent malignant neoplasm characterized by its insidious onset and poor prognosis.Curcumin,a natural phenolic antioxidant extracted from Zingiberaceae family,has various pharmacological effects.Curcumin can inhibit tumor cell proliferation,induce tumor cell apoptosis,suppress tumor cell migration and invasion,regulate tumor epigenetics,inhibit tumor angiogenesis,induce tumor cell autophagy,and delay or reverse tumor drug resistance.This article summarizes the mechanism of curcumin against liver cancer,to provide ideas and methods for the clinical treatment of liver cancer.
作者
赵雅丽
邱华
龙丽娟
覃川福
ZHAO Yali;QIU Hua;LONG Lijuan;QIN Chuanfu(The First Clinical Medical College of Guangxi Medical University,China;Department of Traditional Chinese Medicine,Guangxi Medical University Cancer Hospital,Nanning 530021,China)
出处
《现代药物与临床》
2025年第6期1557-1563,共7页
Drugs & Clinic
基金
国家自然科学基金资助项目(81860889)
广西自然科学基金项目(2024GXNSFAA010131)
广西中医药重点研究室建设项目(桂中医药科教发[2023]9号)
广西(青年)岐黄学者培养项目(桂中医药科教发[2024]8号)。
关键词
姜黄素
肝癌
细胞增殖
细胞凋亡
细胞迁移
细胞侵袭
表观遗传
新血管生成
自噬
耐药
curcumin
liver cancer
cell proliferation
cell apoptosis
cell migration
cell invasion
tumor epigenetics
angiogenesis
autophagy
drug resistance
