摘要
目的:研究口腔鳞状细胞癌(OSCC)组织中,性别决定区Y框蛋白5(SOX5)及细胞型朊病毒蛋白(PrPc)的表达和临床意义。方法:采用免疫组化法检测94例OSCC组织芯片及30例癌旁组织芯片中SOX5及PrPc的表达情况。结果:OSCC组织中SOX5和PrPc表达阳性率分别为69.15%和68.09%,明显高于癌旁组织中的表达(30.00%和20.00%)(P<0.05)。SOX5的表达与淋巴结转移相关(P<0.05),与性别、年龄、浸润深度、TNM分期、分化程度无关(P>0.05);PrPc的表达与肿瘤分化程度、患者年龄相关(P<0.05),与性别、浸润深度、TNM分期、淋巴结转移无关(P>0.05)。SOX5与PrPc的表达呈正相关(r=0.432,P<0.01)。结论:SOX5和PrPc有可能作为OSCC早期诊断的生物标志物。
Objective: To investigate the expression of sex determining reion Y-box 5(SOX5) and cellular prion protein(PrPc) in oral squamous cell carcinoma(OSCC) and its clinical significance. Methods: Immunohistochemistry was performed to detect SOX5 and PrPc levels in tissue microarrays containing 94 OSCC specimens and 30 paracancerous(PC) specimens respectively. Results: The positive rates of SOX5 and PrPc in OSCC were higher than those in PC(69.15% and 68.09% vs 30.00% and 20.00%,P<0.05 respectively). The expression level of SOX5 was correlated with the metastasis(P<0.05), that of PrPc was correlated with the patient age and differentiation of OSCC(P<0.05). The expression of SOX5 was positively correlated with the expression levels of PrPc(r=0.432, P<0.01). Conclusion: SOX5 and PrPc may serve as biomarkers for early diagnosis of OSCC.
作者
王可楹
郑军
刘佳瑞
赵娟
徐江
曾妍
WANG Keying;ZHENG Jun;LIU Jiarui;ZHAO Juan;XU Jiang;ZENG Yan(Key La-boratory of Xinjiang Endemic and Ethnic Disease,China,Shihezi 832000;Department of Stomatology,The First Affiliated Hospi-tal,School of Medicine,Shihezi University)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2020年第4期601-604,共4页
Journal of Practical Stomatology
基金
国家自然科学基金(编号:81560473,81560442)
石河子大学国际合作项目(编号:GJHZ201901)。
