摘要
三级淋巴结构(tertiary lymphoid structure,TLS)是慢性炎症、肿瘤微环境等病理条件下诱导产生的类淋巴器官结构,具有类似次级淋巴器官的功能特征,在多种肿瘤中普遍存在。该综述聚焦于口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中TLS的生物学特性,总结归纳了TLS的组成成分、形成机制、成熟阶段等,系统解析了TLS不同组织成熟度、空间分布和内部组成等特征与OSCC进展、预后的关系,强调了TLS与OSCC中微生物定植的相互作用,以及对OSCC患者放化疗疗效的影响和预测价值。
Tertiary lymphoid structure(TLS)is ectopic lymphoid-like organs induced under pathological conditions such as chronic inflammation and tumor microenvironment,which exhibits functional characteristics similar to secondary lymphoid or-gans and is commonly observed in various cancers.This review focuses on the biological characteristics of TLS in oral squamous cell carcinoma(OSCC),summarizing their components,formation mechanisms,and maturation stages within the tumor microen-vironment.It systematically analyzes the interrelationships between TLS features,including maturation levels,spatial distribu-tion,and cellular composition,and the progression and prognosis of OSCC.The review highlights the bidirectional interactions between TLS and microbial colonization in OSCC,as well as the impact of TLS on the efficacy of radiotherapy and chemotherapy and their potential predictive value for treatment responses.
作者
韩晓晴
沈达
孙纪威
曹亚茹
杜露阳
朱磊
郭丰源
Han Xiaoqing;Shen Da;Sun Jiwei(School of Stomatology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hubei Key Laboratory of Oral and Marillofacial Development and Regeneration,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Stomatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《华中科技大学学报(医学版)》
北大核心
2025年第4期579-586,共8页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
国家自然科学基金资助项目(No.82401191)。
关键词
三级淋巴结构
鳞状细胞癌
免疫治疗
肿瘤微环境
口腔肿瘤
tertiary lymphoid structure
squamous cell carcinoma
immunotherapy
tumor microenvironment
oral neoplasm
