摘要
目的 探讨苍附导痰丸加减治疗对多囊卵巢综合征的临床效果及预后的影响.方法 选取2016年7月-2018年7月在我院妇产科门诊就诊患多囊卵巢综合征且符合纳入标准的100例患者,按照随机数字表法分为试验组与对照组,每组50例.对照组采用口服克罗米芬治疗,试验组在对照组治疗方案的基础上加用苍附导痰丸加减治疗.两组干预时间均为3个月经周期.比较两组患者治疗前后血清学指标(FSH、T、LH、LH/FSH)、中医证候积分以及主要临床症状的发生率,且疗程结束后6个月随访治疗前不孕患者妊娠情况.结果 治疗后,试验组LH、LH/FSH、T改善程度优于对照组,且两组差异有统计学意义(P<0.05);治疗后,试验组患者中医征候积分低于对照组,差异有统计学意义(P<0.05).治疗后,试验组患者喉间痰多、泛恶、月经异常、不孕的发生率显著低于对照组,差异有统计学意义(P<0.05).结论 苍附导痰丸加减治疗多囊卵巢综合征临床效果确切,能有效缓解患者临床症状及改善患者预后,具有较高的临床应用价值.
Objective To explore the effect of the treatment with and without atractylodes and cyperus phlegmabducting pills on clinical efficacy and prognosis of polycystic ovary syndrome(PCOS). Methods 100 patients with PCOS who were treated in the outpatient service of Department of Obstetrics and Gynecology of our hospital from July 2016 to July 2018 and met the inclusion criteria were selected and divided into the experimental group and the control group according to the random number table method,with 50 patients in each group.The control group was treated with oral clomiphene,while the experimental group was treated with atractylodes and cyperus phlegm-abducting pills on the basis of the therapeutic regimen for the control group.The intervention time for both groups was three menstrual cycles.The serum indexes(FSH,T,LH,and LH/FSH),TCM syndrome scores and the incidence of major clinical symptoms before and after treatment were compared between the two groups.The pregnancy of infertile patients before treatment was followed up for 6 months after treatment. Results After treatment,the improvement degree of LH,LH/FSH,and T in the experimental group was superior to that in the control group,and the difference between the two groups was statistically significant(P < 0.05).After treatment,the TCM symptom scores of the patients in the experimental group were lower than those in the control group,and the difference was statistically significant(P < 0.05).After treatment,the incidence of copious phlegm in larynx,nausea,abnormal menstruation and infertility of the patients in the experimental group was significantly lower than that in the control group,and the difference was statistically significant(P < 0.05). Conclusion Atractylodes and cyperus phlegm-abducting pills have a definite clinical effect on the treatment of PCOS.It can effectively relieve the patients’ clinical symptoms and ameliorate their prognosis.Therefore,it is of great value for clinical application.
作者
骆世存
LUO Shicun(Department of Obstetrics and Gynecology,Shenzhen Traditional Chinese Medicine Hospital,Guangdong,Shenzhen 518033,China)
出处
《中国医药科学》
2020年第14期61-63,202,共4页
China Medicine And Pharmacy
基金
广东省深圳市科技计划项目(JCYJ20160428175947624)。
关键词
苍附导痰丸
多囊卵巢综合征
血清学激素
Atractylodes and cyperus phlegm-abducting pills
Polycystic ovary syndrome
Serological hormone
