摘要
目的探讨红细胞平均体积(MCV)联合D-二聚体(D-Dimer)对系统性红斑狼疮(SLE)病情活动性的评估价值。方法收集2016年6月至2019年10月在该院确诊的SLE患者193例为SLE组,收集同期年龄、性别匹配的98例体检健康者为对照组。根据SLE活动度评分(SLEDAI评分)标准将SLE患者分为SLE活动组和SLE非活动组。采用血细胞分析仪XN9000检测MCV水平,采用ACL TOP 700血凝仪检测D-Dimer水平。结果SLE组患者MCV水平为(89.46±8.36)fL,明显低于对照组[(91.69±3.23)fL],且SLE活动组MCV水平[(88.93±4.44)fL]低于SLE非活动组[(91.45±5.91)fL],差异均有统计学意义(P<0.05)。SLE组患者血浆中D-Dimer水平为(1.68±0.07)mg/L,明显高于对照组[(0.35±0.07)mg/L],且SLE活动组D-Dimer水平[(1.77±0.12)mg/L]高于SLE非活动组[(1.49±0.23)mg/L],差异均有统计学意义(P<0.05)。SLE患者的MCV水平与SLEDAI评分呈负相关(r=-0.74,P=0.001),D-Dimer水平与SLEDAI评分呈正相关(r=0.71,P=0.001)。受试者工作特征曲线分析结果显示,单独使用MCV和D-Dimer的曲线下面积分别为0.736和0.624,而MCV联合D-Dimer时的曲线下面积最大,为0.769。结论全血中MCV和血浆中D-Dimer水平与SLE患者病情活动性密切相关,MCV联合D-Dimer评估SLE患者的病情活动性更有价值。
Objective To investigate the value of mean corpuscular volume(MCV)combined with D-dimer in evaluating the disease activity of systemic lupus erythematosus(SLE).Methods Totally 193 SLE patients diagnosed in the hospital from June 2016 to October 2019 were collected as the SLE group,and 98 healthy persons with age and gender matching in the same period were collected as the control group.According to the SLEDAI score,SLE patients were divided into active SLE group and inactive SLE group.MCV level in whole blood was detected by XN9000 hematology analyzer and D-dimer level in plasma was detected by ACL TOP 700 hemagglutination instrument.Results The level of MCV in SLE group was(89.46±8.36)fL,which was significantly lower than that in control group[(91.69±3.23)fL],and the level of MCV in active SLE group[(88.93±4.44)fL]was lower than that in inactive SLE group[(91.45±5.91)fL],the difference was statistically significant(P<0.05).The plasma D-dimer level in SLE group was(1.68±0.07)mg/L,which was significantly higher than that in control group[(0.35±0.07)mg/L],and the level of D-dimer in active SLE group[(1.77±0.12)mg/L]was higher than that in inactive SLE group[(1.49±0.23)mg/L],the difference was statistically significant(P<0.05).There was a negative correlation between MCV level and SLEDAI score(r=-0.74,P=0.001)and there was a positive correlation between D-dimer level and SLEDAI score(r=0.71,P=0.001).The results of receiver operating characteristic curve analysis showed that the area under the curve of MCV and D-dimer alone was 0.736 and 0.624,respectively,while the area under the curve of MCV combined with D-dimer was the largest,which was 0.769.Conclusion MCV in whole blood and D-dimer in plasma are closely related to disease activity of SLE patients.MCV combined with D-dimer is more valuable in evaluating disease activity of SLE patients.
作者
黄云秀
胡婷
王伟佳
HUANG Yunxiu;HU Ting;WANG Weijia(Laboratory Medicine Center,Zhongshan Hospital Affiliated to Sun Yat-sen University,Zhongshan,Guangdong 528403,China)
出处
《检验医学与临床》
CAS
2020年第15期2130-2132,共3页
Laboratory Medicine and Clinic
基金
中山大学附属中山医院医学科研基金项目(B2018063)。
